小柯机器人

近日，法国巴斯德研究所Laure Bally-Cuif等研究人员合作揭示神经干细胞命运决定的动态时空协调。相关论文于2021年4月5日在线发表在《细胞—干细胞》杂志上。

研究人员将整个神经干细胞（NSC）群体在其体内微环境中数周内的动态成像与药理学操作、数学建模和空间统计相结合，并证明NSC使用时空解析的局部反馈信号来协调其在成年斑马鱼脑中分裂的决定。这包括Notch介导的瞬时神经祖细胞的短程抑制和NSC自身的分散效应，并具有9-12天的延迟作用。

从捕获这些相互作用的随机NSC模型表明，这些信号通过谱系进行关联，并控制输出神经元的时空分布。这些结果突显了大脑生发细胞之间发生的局部和时间延迟相互作用如何产生自我传播的动态，从而维持NSC群体的稳态并协调特定的时空相关性。 

据介绍，NSC群体在整个成年脊椎动物大脑中持续存在，并且通过未知机制将其稳态控制在群体水平上。

附：英文原文

Title: Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain

Author: Nicolas Dray, Laure Mancini, Udi Binshtok, Felix Cheysson, Willy Supatto, Pierre Mahou, Sébastien Bedu, Sara Ortica, Emmanuel Than-Trong, Monika Krecsmarik, Sébastien Herbert, Jean-Baptiste Masson, Jean-Yves Tinevez, Gabriel Lang, Emmanuel Beaurepaire, David Sprinzak, Laure Bally-Cuif

Issue&Volume: 2021-04-05

Abstract: Neural stem cell (NSC) populations persist in the adult vertebrate brain over a lifetime, and their homeostasis is controlled at the population level through unknown mechanisms. Here, we combine dynamic imaging of entire NSC populations in their in vivo niche over several weeks with pharmacological manipulations, mathematical modeling, and spatial statistics and demonstrate that NSCs use spatiotemporally resolved local feedback signals to coordinate their decision to divide in adult zebrafish brains. These involve Notch-mediated short-range inhibition from transient neural progenitors and a dispersion effect from the dividing NSCs themselves exerted with a delay of 9–12 days. Simulations from a stochastic NSC lattice model capturing these interactions demonstrate that these signals are linked by lineage progression and control the spatiotemporal distribution of output neurons. These results highlight how local and temporally delayed interactions occurring between brain germinal cells generate self-propagating dynamics that maintain NSC population homeostasis and coordinate specific spatiotemporal correlations.

DOI: 10.1016/j.stem.2021.03.014

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00120-X

Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
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