小柯机器人

美国加州大学Byung Kook Lim课题组最新研究发现，不同的苍白球通路调控帕金森氏病（PD）的行为缺陷。2021年3月15日出版的《自然-神经科学》发表了这项成果。

研究人员探究了外部苍白球（GPe-PV）中表达小白蛋白神经元群体的功能性及其对不同PD相关行为的影响。研究人员发现黑质网状部（SNr）投射GPe-PV神经元和束旁丘脑（PF）投射GPe-PV神经元分别与运动和逆向学习相关。在PD小鼠模型中，研究人员发现对SNr投射GPe-PV神经元的选择性调控减轻了运动功能障碍，而对PF投射GPe-PV神经元的调控则挽救受损的逆向学习。

该发现揭示了两个不同GPe-PV神经元群体对行为的影响，从而为理解PD不同行为缺陷的脑回路基础提供了新的思路。

研究人员表示，基底神经节调控多种行为，包括运动和认知，并对帕金森氏病产生深远影响。但是，尚未在电路水平充分阐明不同基底神经节核的功能组织。

附：英文原文

Title: Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits

Author: Varoth Lilascharoen, Eric Hou-Jen Wang, Nam Do, Stefan Carl Pate, Amanda Ngoc Tran, Christopher Dabin Yoon, Jun-Hyeok Choi, Xiao-Yun Wang, Horia Pribiag, Young-Gyun Park, Kwanghun Chung, Byung Kook Lim

Issue&Volume: 2021-03-15

Abstract: The basal ganglia regulate a wide range of behaviors, including motor control and cognitive functions, and are profoundly affected in Parkinson’s disease (PD). However, the functional organization of different basal ganglia nuclei has not been fully elucidated at the circuit level. In this study, we investigated the functional roles of distinct parvalbumin-expressing neuronal populations in the external globus pallidus (GPe-PV) and their contributions to different PD-related behaviors. We demonstrate that substantia nigra pars reticulata (SNr)-projecting GPe-PV neurons and parafascicular thalamus (PF)-projecting GPe-PV neurons are associated with locomotion and reversal learning, respectively. In a mouse model of PD, we found that selective manipulation of the SNr-projecting GPe-PV neurons alleviated locomotor deficit, whereas manipulation of the PF-projecting GPe-PV neurons rescued the impaired reversal learning. Our findings establish the behavioral importance of two distinct GPe-PV neuronal populations and, thereby, provide a new framework for understanding the circuit basis of different behavioral deficits in the Parkinsonian state.

DOI: 10.1038/s41593-021-00810-y

Source: https://www.nature.com/articles/s41593-021-00810-y

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex