小柯机器人

美国哥伦比亚大学Matteo Porotto等研究人员合作发现，鼻内给药的抑制型脂肽可在雪貂中阻止直接接触型SARS-CoV-2传播。这一研究成果于2021年2月17日在线发表在国际学术期刊《科学》上。

研究人员表示，遏制COVID-19大流行需要减少病毒传播。SARS-CoV-2感染是由病毒刺突蛋白介导的病毒和宿主细胞膜之间的膜融合所引发的。研究人员设计了脂肽融合抑制剂来阻断这一关键的第一步，并基于体外功效和体内生物分布，选择了一种二聚体形式用于动物模型评估。

在严峻条件下，每天对雪貂进行鼻内给药可完全防止SARS-CoV-2直接接触与受感染动物的24小时接触传播（可导致未经治疗的动物100％被感染）。这些脂肽非常稳定，因此可以很容易地转化为安全有效的鼻内预防措施，从而减少SARS-CoV-2的传播。

附：英文原文

Title: Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets

Author: Rory D. de Vries, Katharina S. Schmitz, Francesca T. Bovier, Camilla Predella, Jonathan Khao, Danny Noack, Bart L. Haagmans, Sander Herfst, Kyle N. Stearns, Jennifer Drew-Bear, Sudipta Biswas, Barry Rockx, Gal McGill, N. Valerio Dorrello, Samuel H. Gellman, Christopher A. Alabi, Rik L. de Swart, Anne Moscona, Matteo Porotto

Issue&Volume: 2021/02/17

Abstract: Containment of the COVID-19 pandemic requires reducing viral transmission. SARS-CoV-2 infection is initiated by membrane fusion between the viral and host cell membranes, mediated by the viral spike protein. We have designed lipopeptide fusion inhibitors that block this critical first step of infection, and based on in vitro efficacy and in vivo biodistribution selected a dimeric form for evaluation in an animal model. Daily intranasal administration to ferrets completely prevented SARS-CoV-2 direct-contact transmission during 24-hour co-housing with infected animals, under stringent conditions that resulted in infection of 100% of untreated animals. These lipopeptides are highly stable and thus may readily translate into safe and effective intranasal prophylaxis to reduce transmission of SARS-CoV-2.

DOI: 10.1126/science.abf4896

Source: https://science.sciencemag.org/content/early/2021/02/16/science.abf4896