小柯机器人

荷兰伊拉斯谟MC癌症研究所Marc Hermanus Gerardus Petrus Raaijmakers团队发现，内皮来源的基质细胞有助于造血骨髓的微环境形成。这一研究成果于2021年2月8日在线发表在国际学术期刊《细胞—干细胞》上。

研究人员在人类胎儿和再生骨髓中鉴定出共同表达内皮和基质标志物的稀有LNGFR⁺细胞。这种内皮细胞亚群显示出与内皮细胞向间充质转变（EndoMT）一致的转录重编程，并且可以在移植后生成重组骨髓（BM）微环境的多能基质细胞。小鼠中的单细胞转录组学和谱系追踪证实了EndoMT对骨前体和造血微环境库的强大持续贡献。白细胞介素33（IL-33）在EndoMT细胞亚群中过表达，并通过ST2受体信号驱动这一转化过程。

这些数据揭示了从小鼠和人类内皮细胞生成组织形成的骨髓基质细胞（BMSC），并可能对人类组织再生具有指导意义。 

据了解，BMSC在组织维持和再生中起关键作用。 但是，它们的起源仍然不完全清楚。

附：英文原文

Title: Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation

Author: Keane Jared Guillaume Kenswil, Paola Pisterzi, Gonzalo Sánchez-Duffhues, Claire van Dijk, Andrea Lolli, Callie Knuth, Byambasuren Vanchin, Adrian Christopher Jaramillo, Remco Michiel Hoogenboezem, Mathijs Arnoud Sanders, Jacqueline Feyen, Tom Cupedo, Ivan G. Costa, Ronghui Li, Eric Moniqué Johannes Bindels, Kirsten Lodder, Bianca Blom, Pieter Koen Bos, Marie-José Goumans, Peter ten Dijke, Eric Farrell, Guido Krenning, Marc Hermanus Gerardus Petrus Raaijmakers

Issue&Volume: 2021-02-08

Abstract: Bone marrow stromal cells (BMSCs) play pivotal roles in tissue maintenance and regeneration.Their origins, however, remain incompletely understood. Here we identify rare LNGFR+ cells in human fetal and regenerative bone marrow that co-express endothelial andstromal markers. This endothelial subpopulation displays transcriptional reprogrammingconsistent with endothelial-to-mesenchymal transition (EndoMT) and can generate multipotentstromal cells that reconstitute the bone marrow (BM) niche upon transplantation. Single-celltranscriptomics and lineage tracing in mice confirm robust and sustained contributionsof EndoMT to bone precursor and hematopoietic niche pools. Interleukin-33 (IL-33)is overexpressed in subsets of EndoMT cells and drives this conversion process throughST2 receptor signaling. These data reveal generation of tissue-forming BMSCs frommouse and human endothelial cells and may be instructive for approaches to human tissue regeneration.

DOI: 10.1016/j.stem.2021.01.006

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(21)00006-0

Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
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