美国国立癌症研究所Louis M. Staudt小组揭示出治疗反应异常型癌症的分子特征。该研究于2020年11月19日在线发表于国际一流学术期刊《癌细胞》。
Title: Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment
Author: David A. Wheeler, Naoko Takebe, Toshinori Hinoue, Katherine A. Hoadley, Maria F. Cardenas, Alina M. Hamilton, Peter W. Laird, Linghua Wang, Adrienne Johnson, Ninad Dewal, Vincent Miller, David Pieyro, Manuel Castro de Moura, Manel Esteller, Hui Shen, Jean Claude Zenklusen, Roy Tarnuzzer, Lisa M. McShane, James V. Tricoli, Paul M. Williams, Irina Lubensky, Geraldine OSullivan-Coyne, Elise C. Kohn, Richard F. Little, Jeffrey White, Shakun Malik, Lyndsay Harris, Carol Weil, Alice P. Chen, Chris Karlovich, Brian Rodgers, Lalitha Shankar, Paula Jacobs, Tracy Nolan, Jianhong Hu, Donna M. Muzny, Harshavardhan Doddapaneni, Viktoriya Korchina, Julie Gastier-Foster, Jay Bowen, Kristen Leraas, Elijah F. Edmondson, James H. Doroshow, Barbara A. Conley, S. Percy Ivy, Louis M. Staudt
Issue&Volume: 2020-11-19
Abstract: A small fraction of cancer patients with advanced disease survive significantly longerthan patients with clinically comparable tumors. Molecular mechanisms for exceptionalresponses to therapy have been identified by genomic analysis of tumor biopsies fromindividual patients. Here, we analyzed tumor biopsies from an unbiased cohort of 111exceptional responder patients using multiple platforms to profile genetic and epigeneticaberrations as well as the tumor microenvironment. Integrative analysis uncoveredplausible mechanisms for the therapeutic response in nearly a quarter of the patients.The mechanisms were assigned to four broad categories—DNA damage response, intracellularsignaling, immune engagement, and genetic alterations characteristic of favorableprognosis—with many tumors falling into multiple categories. These analyses revealedsynthetic lethal relationships that may be exploited therapeutically and rare geneticlesions that favor therapeutic success, while also providing a wealth of testablehypotheses regarding oncogenic mechanisms that may influence the response to cancertherapy.
DOI: 10.1016/j.ccell.2020.10.015
Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30546-8
Cancer Cell:《癌细胞》,创刊于2002年。隶属于细胞出版社,最新IF:38.585
官方网址:https://www.cell.com/cancer-cell/home
投稿链接:https://www.editorialmanager.com/cancer-cell/default.aspx
本期文章:《癌细胞》:Online/在线发表