小柯机器人

西班牙巴伦西亚大学Isabel Farias和Jose Manuel Morante-Redolat团队在研究中取得进展。他们研究发现成体神经干细胞（SCs）通过TNF-α受体信号通路响应全身炎症。相关论文发表在2020年11月17日出版的《细胞-干细胞》杂志上。

研究人员研发了一种多级策略来分析这些单神经SC（NSC）的状态，以发现调节其静态/激活水平的信号。研究表明状态之间的过渡发生在体内，并且可以在培养细胞中观察激活和始发态但非静态的细胞。研究还显示，外周诱导的炎症促进了由肿瘤坏死因子α（TNF-α）通过其受体TNF受体2（TNFR2）介导的致敏NSC（pNSCs）瞬时激活，并在TNF受体1中恢复了静止（TNFR1）依赖的方式。该研究数据确定了促进NSC开启的信号传导途径，并提出了新的概念，即SC可以响应系统环境。

据悉，SCs在细胞周期与尚且未知的静态细胞之间转换。已从室管膜下区（SEZ）获得了静态、始发态和激活态NSC的转录组，但尚不清楚这些状态在稳态下的功能调节。

附：英文原文

Title: Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling

Author: Germán Belenguer, Pere Duart-Abadia, Antonio Jordán-Pla, Ana Domingo-Muelas, Laura Blasco-Chamarro, Sacri R. Ferrón, Jose Manuel Morante-Redolat, Isabel Farias

Issue&Volume: 2020-11-17

Abstract: Adult stem cells (SCs) transit between the cell cycle and a poorly defined quiescentstate. Single neural SCs (NSCs) with quiescent, primed-for-activation, and activatedcell transcriptomes have been obtained from the subependymal zone (SEZ), but the functionalregulation of these states under homeostasis is not understood. Here, we develop amultilevel strategy to analyze these NSC states with the aim to uncover signals thatregulate their level of quiescence/activation. We show that transitions between statesoccur in vivo and that activated and primed, but not quiescent, states can be captured and studiedin culture. We also show that peripherally induced inflammation promotes a transientactivation of primed NSCs (pNSCs) mediated by tumor necrosis factor α (TNF-α) actingthrough its receptor, TNF receptor 2 (TNFR2), and a return to quiescence in a TNFreceptor 1 (TNFR1)-dependent manner. Our data identify a signaling pathway promotingNSC alertness and add to the emerging concept that SCs can respond to the systemicmilieu.

DOI: 10.1016/j.stem.2020.10.016

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30510-5

Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
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