美国南加州大学J. Gage Crump研究团队利用谱系分析揭示出内胚层对脊椎动物垂体发育的贡献。2020年10月23日出版的《科学》杂志发表了这项成果。
Title: Lineage analysis reveals an endodermal contribution to the vertebrate pituitary
Author: Peter Fabian, Kuo-Chang Tseng, Joanna Smeeton, Joseph J. Lancman, P. Duc Si Dong, Robert Cerny, J. Gage Crump
Issue&Volume: 2020/10/23
Abstract: Vertebrate sensory organs arise from epithelial thickenings called placodes. Along with neural crest cells, cranial placodes are considered ectodermal novelties that drove evolution of the vertebrate head. The anterior-most placode generates the endocrine lobe [adenohypophysis (ADH)] of the pituitary, a master gland controlling growth, metabolism, and reproduction. In addition to known ectodermal contributions, we use lineage tracing and time-lapse imaging in zebrafish to identify an endodermal contribution to the ADH. Single-cell RNA sequencing of the adult pituitary reveals similar competency of endodermal and ectodermal epithelia to generate all endocrine cell types. Further, endoderm can generate a rudimentary ADH-like structure in the near absence of ectodermal contributions.
DOI: 10.1126/science.aba4767
Source: https://science.sciencemag.org/content/370/6515/463
本期文章:《科学》:Volume 370 Issue 6515