小柯机器人

近日，美国西北大学David L. McLean及其团队的研究揭示斑马鱼脊髓发育中运动前抑制的有序区室化。2020年10月23日，国际知名学术期刊《科学》发表了这一成果。

Title: Orderly compartmental mapping of premotor inhibition in the developing zebrafish spinal cord

Author: Sandeep Kishore, Eli B. Cadoff, Moneeza A. Agha, David L. McLean

Issue&Volume: 2020/10/23

Abstract: In vertebrates, faster movements involve the orderly recruitment of different types of spinal motor neurons. However, it is not known how premotor inhibitory circuits are organized to ensure alternating motor output at different movement speeds. We found that different types of commissural inhibitory interneurons in zebrafish form compartmental microcircuits during development that align inhibitory strength and recruitment order. Axonal microcircuits develop first and provide the most potent premotor inhibition during the fastest movements, followed by perisomatic microcircuits, and then dendritic microcircuits that provide the weakest inhibition during the slowest movements. The conversion of a temporal sequence of neuronal development into a spatial pattern of inhibitory connections provides an “ontogenotopic” solution to the problem of shaping spinal motor output at different speeds of movement.

DOI: 10.1126/science.abb4608

Source: https://science.sciencemag.org/content/370/6515/431