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多反应性中和B细胞为大流行性流感病毒提供防御
2020-10-25 22:02
来源：小柯机器人

美国芝加哥大学Patrick C. Wilson课题组发现，多反应性中和B细胞为大流行性流感病毒提供防御。2020年10月22日，《免疫》杂志在线发表了这项成果。

通过分析由多种流感病毒疫苗和感染诱导的B细胞衍生的500多种单克隆抗体（mAb），研究人员发现靶向保守的中和流感病毒血凝素表位的mAb具有多反应性。多反应性单克隆抗体由于其广泛的病毒结合宽度而被新型病毒暴露优先诱导。多反应性可通过增加抗体的柔韧性来增强mAb的病毒结合强度，从而适应不完全保守的表位。
 
最后，研究人员发现亲和力成熟的多反应性B细胞通常来自种系多反应性B细胞，这些细胞优先被选择参与B细胞反应。总之，这些数据表明多反应性是保守表位靶向抗体的有益特征。
 
据了解，多反应性是单个抗体结合多种分子上不同的抗原的能力，并且是病原体暴露后诱导抗体的共同特征。但是，关于多反应性在抗流感病毒抗体反应中的作用知之甚少。
 
附：英文原文

Title: Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

Author: Jenna J. Guthmiller, Linda Yu-Ling Lan, Monica L. Fernández-Quintero, Julianna Han, Henry A. Utset, Dalia J. Bitar, Natalie J. Hamel, Olivia Stovicek, Lei Li, Micah Tepora, Carole Henry, Karlynn E. Neu, Haley L. Dugan, Marta T. Borowska, Yao-Qing Chen, Sean T.H. Liu, Christopher T. Stamper, Nai-Ying Zheng, Min Huang, Anna-Karin E. Palm, Adolfo García-Sastre, Raffael Nachbagauer, Peter Palese, Lynda Coughlan, Florian Krammer, Andrew B. Ward, Klaus R. Liedl, Patrick C. Wilson

Issue&Volume: 2020-10-22

Abstract: Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon pathogen exposure. However, little is known about the role of polyreactivity during anti-influenza virus antibody responses. By analyzing more than 500 monoclonal antibodies (mAbs) derived from B cells induced by numerous influenza virus vaccines and infections, we found mAbs targeting conserved neutralizing influenza virus hemagglutinin epitopes were polyreactive. Polyreactive mAbs were preferentially induced by novel viral exposures due to their broad viral binding breadth. Polyreactivity augmented mAb viral binding strength by increasing antibody flexibility, allowing for adaption to imperfectly conserved epitopes. Lastly, we found affinity-matured polyreactive B cells were typically derived from germline polyreactive B cells that were preferentially selected to participate in B cell responses over time. Together, our data reveal that polyreactivity is a beneficial feature of antibodies targeting conserved epitopes.

DOI: 10.1016/j.immuni.2020.10.005

Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30446-5

Immunity：《免疫》，创刊于1994年。隶属于细胞出版社，最新IF：43.474
官方网址：https://www.cell.com/immunity/home
投稿链接：https://www.editorialmanager.com/immunity/default.aspx


本期文章：《免疫》：Online/在线发表

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