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全面评估不同状态下心脏的能源使用情况
2020-10-17 23:03

美国宾夕法尼亚大学Zolt Arany研究组全面评估了衰竭与正常心脏的能源使用情况。这一研究成果发表在2020年10月16日出版的国际学术期刊《科学》上。

研究人员对110位有或没有心力衰竭的患者的动脉、冠状窦和股静脉的血液进行了代谢组学研究,从而量化了人体心脏和腿部对277种代谢物(包括所有主要营养素)的摄取和释放。心脏主要消耗脂肪酸,而出乎意料的是,葡萄糖消耗很少;谷氨酰胺和其他富含氮的氨基酸的分泌表明了活性蛋白分解,其降解速率约为腿部的10倍;并释放出三羧酸循环的中间体,从而平衡了氨基酸分解引起的动脉粥样硬化。
 
心脏和腿部消耗的酮、谷氨酸和乙酸盐与循环水平成正比,进而表明可用性是这些底物消耗的关键驱动因素。衰竭的心脏消耗了更多的酮和乳酸,并且蛋白水解率更高。这些数据提供了人类心脏能源使用的全面和定量信息。
 
据悉,心脏消耗循环养分来为收缩功能,但缺乏对人类心脏能源使用的全面了解。
 
附:英文原文

Title: Comprehensive quantification of fuel use by the failing and nonfailing human heart

Author: Danielle Murashige, Cholsoon Jang, Michael Neinast, Jonathan J. Edwards, Alexis Cowan, Matthew C. Hyman, Joshua D. Rabinowitz, David S. Frankel, Zolt Arany

Issue&Volume: 2020/10/16

Abstract: The heart consumes circulating nutrients to fuel lifelong contraction, but a comprehensive mapping of human cardiac fuel use is lacking. We used metabolomics on blood from artery, coronary sinus, and femoral vein in 110 patients with or without heart failure to quantify the uptake and release of 277 metabolites, including all major nutrients, by the human heart and leg. The heart primarily consumed fatty acids and, unexpectedly, little glucose; secreted glutamine and other nitrogen-rich amino acids, indicating active protein breakdown, at a rate ~10 times that of the leg; and released intermediates of the tricarboxylic acid cycle, balancing anaplerosis from amino acid breakdown. Both heart and leg consumed ketones, glutamate, and acetate in direct proportionality to circulating levels, indicating that availability is a key driver for consumption of these substrates. The failing heart consumed more ketones and lactate and had higher rates of proteolysis. These data provide a comprehensive and quantitative picture of human cardiac fuel use.

DOI: 10.1126/science.abc8861

Source: https://science.sciencemag.org/content/370/6514/364

Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037
官方网址:https://www.sciencemag.org/
投稿链接:https://cts.sciencemag.org/scc/#/login

本期文章:《科学》:Volume 370 Issue 6514

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