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细胞核可测量细胞本体感受的形状变化来控制动态细胞行为
2020-10-17 23:07

西班牙巴塞罗那科技研究所Verena Ruprecht、Stefan Wieser等研究人员合作发现,细胞核可测量细胞本体感受的形状变化来控制动态细胞行为。这一研究成果发表在2020年10月16日出版的国际学术期刊《科学》上。

研究人员使用斑马鱼模型发现最大的细胞器——细胞核,可作为一个弹性变形仪,使细胞能够测量细胞形状的变形。核伸展后内核膜的展开提供有关细胞形状变化的物理信息,并自适应性激活钙依赖性机械转导途径来控制肌动球蛋白的收缩性和迁移可塑性。
 
这些数据表明,细胞核为细胞的本体感受建立了功能模块,从而使细胞能够感知形状变化来让细胞行为适应其微环境。
 
据了解,物理微环境在组织发育和体内平衡过程中调节细胞行为。在组织内的机械应力和物理空间限制下,单个细胞如何解码有关其几何形状的信息仍然未知。
 
附:英文原文

Title: The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

Author: Valeria Venturini, Fabio Pezzano, Frederic Català Castro, Hanna-Maria Hkkinen, Senda Jiménez-Delgado, Mariona Colomer-Rosell, Monica Marro, Queralt Tolosa-Ramon, Sonia Paz-López, Miguel A. Valverde, Julian Weghuber, Pablo Loza-Alvarez, Michael Krieg, Stefan Wieser, Verena Ruprecht

Issue&Volume: 2020/10/16

Abstract: The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress and physical space constraints within tissues remains largely unknown. Here, using a zebrafish model, we show that the nucleus, the biggest cellular organelle, functions as an elastic deformation gauge that enables cells to measure cell shape deformations. Inner nuclear membrane unfolding upon nucleus stretching provides physical information on cellular shape changes and adaptively activates a calcium-dependent mechanotransduction pathway, controlling actomyosin contractility and migration plasticity. Our data support that the nucleus establishes a functional module for cellular proprioception that enables cells to sense shape variations for adapting cellular behavior to their microenvironment.

DOI: 10.1126/science.aba2644

Source: https://science.sciencemag.org/content/370/6514/eaba2644

Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037
官方网址:https://www.sciencemag.org/
投稿链接:https://cts.sciencemag.org/scc/#/login

本期文章:《科学》:Volume 370 Issue 6514

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