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科学家揭示细胞大小变化的秘密
2020-10-17 22:55

法国巴黎文理研究大学Yohanns Bellache团队和美国密西根大学David K. Lubensky团队合作研究发现,顶端应力纤维可在细胞机械反应和上皮组织区域之间缩放。2020年10月16日出版的《科学》杂志发表了这一成果。

通过检测果蝇p背部胸膜上皮细胞对形态发生力的反应,研究人员发现锚定在粘附连接处的顶端应力纤维(aSFs)的数量与细胞顶面积成比例,这限制了在面临较大机械应力时细胞的伸长。aSFs招募Hippo信号通路的成分,从而随区域缩放Hippo信号传导和增殖。在较大细胞中由三细胞连接调控的aSF成核速率和寿命的增加促进了这种缩放。 

该工作揭示了发育、内稳态和修复涉及由机械力驱动的上皮细胞大小变化,同时阐明了机械敏感性如何随细胞大小而变化。

据了解,在整个发育以及许多生理过程中,生物体都会根据其大小调整其特性和行为。 但是,这种尺寸缩放比例在应用于细胞力学和机械感知方面仍然知之甚少。

附:英文原文

Title: Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue

Author: Jesús M. López-Gay, Hayden Nunley, Meryl Spencer, Florencia di Pietro, Boris Guirao, Floris Bosveld, Olga Markova, Isabelle Gaugue, Stéphane Pelletier, David K. Lubensky, Yohanns Bellache

Issue&Volume: 2020/10/16

Abstract: Biological systems tailor their properties and behavior to their size throughout development and in numerous aspects of physiology. However, such size scaling remains poorly understood as it applies to cell mechanics and mechanosensing. By examining how the Drosophila pupal dorsal thorax epithelium responds to morphogenetic forces, we found that the number of apical stress fibers (aSFs) anchored to adherens junctions scales with cell apical area to limit larger cell elongation under mechanical stress. aSFs cluster Hippo pathway components, thereby scaling Hippo signaling and proliferation with area. This scaling is promoted by tricellular junctions mediating an increase in aSF nucleation rate and lifetime in larger cells. Development, homeostasis, and repair entail epithelial cell size changes driven by mechanical forces; our work highlights how, in turn, mechanosensitivity scales with cell size.

DOI: 10.1126/science.abb2169

Source: https://science.sciencemag.org/content/370/6514/eabb2169

Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037
官方网址:https://www.sciencemag.org/
投稿链接:https://cts.sciencemag.org/scc/#/login

本期文章:《科学》:Volume 370 Issue 6514

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