小柯机器人

局部轴突传导塑造神经序列的时空特性
2020-10-17 23:15

美国纽约大学Michael A. Long小组发现,局部轴突传导塑造神经序列的时空特性。相关论文于2020年10月15日发表于国际学术期刊《细胞》。

研究人员探索了成年斑胸草鸟前脑的HVC中的运动前序列,这些序列对于精准求爱歌曲的表现至关重要。研究人员使用高密度硅探针来测量了与歌唱相关的种群活动,并将这些观察结果与来自一系列网络模型的预测进行比较。结果支持了一种回路架构,即依次活动的神经元之间的异质延迟影响了HVC前运动神经元活动的时空模式。
 
研究人员测量了几个延迟源的影响,并发现主要的贡献者是通过HVC内的轴突侧支缓慢传导,通常会为序列中的每个关联增加1至7.5毫秒。因此,局部轴突“延迟线”可以在确定神经回路的动态库中起重要作用。
 
据悉,在各种行为和认知过程中都观察到了神经元的依次激活,但是其潜在的回路机制仍然知之甚少。
 
附:英文原文

Title: Local Axonal Conduction Shapes the Spatiotemporal Properties of Neural Sequences

Author: Robert Egger, Yevhen Tupikov, Margot Elmaleh, Kalman A. Katlowitz, Sam E. Benezra, Michel A. Picardo, Felix Moll, Jrgen Kornfeld, Dezhe Z. Jin, Michael A. Long

Issue&Volume: 2020/10/15

Abstract: Sequential activation of neurons has been observed during various behavioral and cognitiveprocesses, but the underlying circuit mechanisms remain poorly understood. Here, weinvestigate premotor sequences in HVC (proper name) of the adult zebra finch forebrainthat are central to the performance of the temporally precise courtship song. We usehigh-density silicon probes to measure song-related population activity, and we comparethese observations with predictions from a range of network models. Our results supporta circuit architecture in which heterogeneous delays between sequentially active neuronsshape the spatiotemporal patterns of HVC premotor neuron activity. We gauge the impactof several delay sources, and we find the primary contributor to be slow conductionthrough axonal collaterals within HVC, which typically adds between 1 and 7.5 ms foreach link within the sequence. Thus, local axonal “delay lines” can play an importantrole in determining the dynamical repertoire of neural circuits.

DOI: 10.1016/j.cell.2020.09.019

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31160-0

Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
官方网址:https://www.cell.com/
投稿链接:https://www.editorialmanager.com/cell/default.aspx

本期文章:《细胞》:Volume 183 Issue 2

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