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原核生物的蛇毒素能够产生多种抗病毒分子
2020-09-18 15:45

近日,以色列魏茨曼科学研究所Rotem Sorek等研究人员发现,原核生物的蛇毒素能够产生多种抗病毒分子。这一研究成果于2020年9月16日在线发表在国际学术期刊《自然》上。

研究人员发现,真核生物蛇毒素源自细菌和古细菌蛋白进化枝,可防止噬菌体感染。原核蛇毒素(pVip)产生一组修饰的核糖核苷酸,包括ddhCTP、ddhGTP和ddhUTP。研究人员进一步表明,pVip通过抑制病毒聚合酶依赖性转录来防止T7噬菌体感染,这意味着与动物蛇毒素相似的抗病毒作用机制。这些结果揭示了由细菌免疫系统产生的天然抗病毒化合物。
 
据了解,蛇毒素是干扰素诱导的细胞蛋白,这在动物中保守存在。它通过产生称为ddhCTP(3’-deoxy-3’4’-didehydro-CTP)的核糖核苷酸来抑制多种病毒的复制,其可充当病毒RNA聚合酶的链终止剂。
 
附:英文原文

Title: Prokaryotic viperins produce diverse antiviral molecules

Author: Aude Bernheim, Adi Millman, Gal Ofir, Gilad Meitav, Carmel Avraham, Helena Shomar, Masha M. Rosenberg, Nir Tal, Sarah Melamed, Gil Amitai, Rotem Sorek

Issue&Volume: 2020-09-16

Abstract: Viperin is an interferon-induced cellular protein conserved in animals1. It was shown to inhibit the replication of multiple viruses by producing a ribonucleotide called 3’-deoxy-3’4’-didehydro-CTP (ddhCTP), which acts as a chain terminator for the viral RNA polymerase2. Here we show that the eukaryotic viperin has originated from a clade of bacterial and archaeal proteins that protect against phage infection. Prokaryotic viperins (pVips) produce a set of modified ribonucleotides that include ddhCTP, as well as ddhGTP and ddhUTP. We further provide evidence that pVips protect against T7 phage infection by inhibiting viral polymerase-dependent transcription, implying an anti-viral mechanism of action similar to the animal viperin. Our results unveil a potential repository of natural antiviral compounds produced by bacterial immune systems.

DOI: 10.1038/s41586-020-2762-2

Source: https://www.nature.com/articles/s41586-020-2762-2

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:69.504
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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