清华大学傅肃能研究组发现,丙糖激酶控制果糖的脂肪生成潜能和饮食耐受性。2020年8月19日,《细胞—代谢》杂志在线发表了这项成果。
Title: Triose Kinase Controls the Lipogenic Potential of Fructose and Dietary Tolerance
Author: Lei Liu, Tian Li, Yilie Liao, Yalong Wang, Yang Gao, Haikun Hu, Haipeng Huang, Fang Wu, Ye-Guang Chen, Shuhua Xu, Suneng Fu
Issue&Volume: 2020-08-19
Abstract: The surge in fructose consumption is a major factor behind the rapid rise of nonalcoholicfatty liver disease in modern society. Through flux and genetic analyses, we demonstratethat fructose is catabolized at a much higher rate than glucose, and triose kinase(TK) couples fructolysis with lipogenesis metabolically and transcriptionally. Inthe absence of TK, fructose oxidation is accelerated through the activation of aldehydedehydrogenase (ALDH) and serine biosynthesis, accompanied by increased oxidative stressand fructose aversion. TK is also required by the endogenous fructolysis pathway todrive lipogenesis and hepatic triglyceride accumulation under high-fat diet and leptin-deficientconditions. Intriguingly, a nonsynonymous TK allele (rs2260655_A) segregated during human migration out of Africa behaves as TK null for its inabilityto rescue fructose toxicity and increase hepatic triglyceride accumulation. Therefore,we posit TK as a metabolic switch controlling the lipogenic potential of fructose and its dietary tolerance.
DOI: 10.1016/j.cmet.2020.07.018
Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30413-7
Cell Metabolism:《细胞—代谢》,创刊于2005年。隶属于细胞出版社,最新IF:31.373
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本期文章:《细胞—代谢》:Online/在线发表