小柯机器人

近日，英国伦敦大学学院Marc Aurel Busche等研究人员总结了淀粉样β蛋白和tau蛋白在阿尔茨海默氏病中的协同作用。2020年8月10日，国际知名学术期刊《自然—神经科学》在线发表了这一论文。

Title: Synergy between amyloid-β and tau in Alzheimer’s disease

Author: Marc Aurel Busche, Bradley T. Hyman

Issue&Volume: 2020-08-10

Abstract: Patients with Alzheimer’s disease (AD) present with both extracellular amyloid-β (Aβ) plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years, the prevailing view of AD pathogenesis has been that changes in Aβ precipitate the disease process and initiate a deleterious cascade involving tau pathology and neurodegeneration. Beyond this ‘triggering’ function, it has been typically presumed that Aβ and tau act independently and in the absence of specific interaction. However, accumulating evidence now suggests otherwise and contends that both pathologies have synergistic effects. This could not only help explain negative results from anti-Aβ clinical trials but also suggest that trials directed solely at tau may need to be reconsidered. Here, drawing from extensive human and disease model data, we highlight the latest evidence base pertaining to the complex Aβ–tau interaction and underscore its crucial importance to elucidating disease pathogenesis and the design of next-generation AD therapeutic trials.

DOI: 10.1038/s41593-020-0687-6

Source: https://www.nature.com/articles/s41593-020-0687-6

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex