小柯机器人

美国加州大学圣迭戈分校Mark H. Tuszynski、Steven Ceto等研究人员合作发现，神经干细胞移植能够形成广泛的突触网络，从而在脊髓损伤后与宿主回路整合。2020年8月5日，《细胞—干细胞》杂志在线发表了这项成果。

Title: Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury

Author: Steven Ceto, Kohei J. Sekiguchi, Yoshio Takashima, Axel Nimmerjahn, Mark H. Tuszynski

Issue&Volume: 2020-08-05

Abstract: Neural stem/progenitor cell (NSPC) grafts can integrate into sites of spinal cordinjury (SCI) and generate neuronal relays across lesions that can provide functionalbenefit. To determine if and how grafts become synaptically organized and connectwith host systems, we performed calcium imaging of NSPC grafts in SCI sites in vivo and in adult spinal cord slices. NSPC grafts organize into localized and spontaneouslyactive synaptic networks. Optogenetic stimulation of host corticospinal tract axonsregenerating into grafts elicited distinct and segregated neuronal network responsesthroughout the graft. Moreover, optogenetic stimulation of graft-derived axons extendingfrom the graft into the denervated spinal cord also triggered local host neuronalnetwork responses. In vivo imaging revealed that behavioral stimulation likewise elicited focal synaptic responseswithin grafts. Thus neural progenitor grafts can form functional synaptic subnetworkswhose activity patterns resemble intact spinal cord.

DOI: 10.1016/j.stem.2020.07.007

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30345-3

Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
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