小柯机器人

德国柏林洪堡大学Matthew E. Larkum、Naoya Takahashi等研究人员合作发现，主动树突电流控制感知中的递减皮质输出。该研究于2020年8月3日在线发表于国际一流学术期刊《自然—神经科学》。

Title: Active dendritic currents gate descending cortical outputs in perception

Author: Naoya Takahashi, Christian Ebner, Johanna Sigl-Glckner, Sara Moberg, Svenja Nierwetberg, Matthew E. Larkum

Issue&Volume: 2020-08-03

Abstract: The output of cortical columns is routed to different downstream targets via distinct pathways: cortico-cortical and cortico-subcortical. It is as yet unclear what roles these pathways play in perception, and which cellular and circuit mechanisms regulate their gating. We recently showed that activation of the apical dendrites of layer 5 (L5) pyramidal neurons correlates with the threshold for perception, but these neurons come in two classes that target either other cortical or subcortical areas. In the present study, we took advantage of transgenic mouse lines for these L5 subclasses to determine their relative contributions to the perceptual process. We found that the activation of apical dendrites in neurons of the somatosensory cortex, which project to subcortical regions, almost exclusively determined the detection of tactile stimuli in mice. Our results suggest that dendritic activation drives context-dependent interactions between cortex and subcortical regions, including the higher-order thalamus, superior colliculus and striatum, which are crucial for perception.

DOI: 10.1038/s41593-020-0677-8

Source: https://www.nature.com/articles/s41593-020-0677-8

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex