小柯机器人

展望ENCODE计划
2020-08-01 23:21

美国斯坦福大学Michael P. Snyder等研究人员对ENCODE计划进行了展望。这一论文于2020年7月29日出版的国际学术期刊《自然》上。

研究人员表示,ENCODE(Encylopedia of DNA Elements)计划于2003年启动,其长期目标是开发人类基因组中功能元素图谱。这些包括基因、与基因调控相关的生化区域(例如,转录因子结合位点、开放染色质和组蛋白标记)以及转录本亚型。这些标记是候选顺式调控元件(cCRE)的位点,这些元件可能在调控基因表达中发挥功能性作用。该项目已扩展到模型生物,尤其是小鼠。

在ENCODE的第三阶段,研究人员分别为人类和小鼠生成了将近100万和30余万的cCRE注释,这些注释为科学界提供了宝贵的资源。

附:英文原文

Title: Perspectives on ENCODE

Author: Michael P. Snyder, Thomas R. Gingeras, Jill E. Moore, Zhiping Weng, Mark B. Gerstein, Bing Ren, Ross C. Hardison, John A. Stamatoyannopoulos, Brenton R. Graveley, Elise A. Feingold, Michael J. Pazin, Michael Pagan, Daniel A. Gilchrist, Benjamin C. Hitz, J. Michael Cherry, Bradley E. Bernstein, Eric M. Mendenhall, Daniel R. Zerbino, Adam Frankish, Paul Flicek, Richard M. Myers

Issue&Volume: 2020-07-29

Abstract: The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression1. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community. The authors summarize the history of the ENCODE Project, the achievements of ENCODE 1 and ENCODE 2, and how the new data generated and analysed in ENCODE 3 complement the previous phases.

DOI: 10.1038/s41586-020-2449-8

Source: https://www.nature.com/articles/s41586-020-2449-8

Nature:《自然》,创刊于1869年。隶属于施普林格·自然出版集团,最新IF:43.07
官方网址:http://www.nature.com/
投稿链接:http://www.nature.com/authors/submit_manuscript.html


本期文章:《自然》:Online/在线发表

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