小柯机器人

荷兰阿姆斯特丹大学的Klaas P. J. M. van Gisbergen研究团队的最新工作表明，组织驻留型CD8⁺记忆T细胞（TRM细胞）塑造局部和全身性次级T细胞反应。2020年7月13日，《自然—免疫学》杂志在线发表了这项成果。

附：英文原文

Title: Tissue-resident memory CD8 + T cells shape local and systemic secondary T cell responses

Author: Felix M. Behr, Loreto Parga-Vidal, Natasja A. M. Kragten, Teunis J. P. van Dam, Thomas H. Wesselink, Brian S. Sheridan, Ramon Arens, Rene A. W. van Lier, Regina Stark, Klaas P. J. M. van Gisbergen

Issue&Volume: 2020-07-13

Abstract: Tissue-resident memory CD8+ T cells (TRM cells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue confinement and contribution to recall responses is unclear. We developed a unique lineage tracer mouse model exploiting the TRM-defining transcription factor homolog of Blimp-1 in T cells (Hobit) to fate map the TRM progeny in secondary responses. After reinfection, a sizeable fraction of secondary memory T cells in the circulation developed downstream of TRM cells. These tissue-experienced ex-TRM cells shared phenotypic properties with the effector memory T cell population but were transcriptionally and functionally distinct from other secondary effector memory T cell cells. Adoptive transfer experiments of TRM cells corroborated their potential to form circulating effector and memory cells during recall responses. Moreover, specific ablation of primary TRM cell populations substantially impaired the secondary T cell response, both locally and systemically. Thus, TRM cells retain developmental plasticity and shape both local and systemic T cell responses on reinfection. Van Gisbergen and colleagues show that tissue-resident memory T cells, genetically marked in Hobit reporter mice, can exit tissues upon reinfection and contribute to systemic memory responses.

DOI: 10.1038/s41590-020-0723-4

Source: https://www.nature.com/articles/s41590-020-0723-4

Nature Immunology：《自然—免疫学》，创刊于2000年。隶属于施普林格·自然出版集团，最新IF：31.25
官方网址：https://www.nature.com/ni/
投稿链接：https://mts-ni.nature.com/cgi-bin/main.plex