瑞士洛桑大学Michel Gilliet研究团队发现,共生的皮肤微生物菌群能够在受伤的皮肤上触发I型干扰素依赖性先天性修复反应。该项研究成果发表于2020年7月13日在线发表在《自然—免疫学》杂志上。
Author: Jeremy Di Domizio, Cyrine Belkhodja, Pauline Chenuet, Anissa Fries, Timothy Murray, Paula Marcos Mondjar, Olivier Demaria, Curdin Conrad, Bernhard Homey, Sabine Werner, Daniel E. Speiser, Bernhard Ryffel, Michel Gilliet
Issue&Volume: 2020-07-13
Abstract: Skin wounds heal by coordinated induction of inflammation and tissue repair, but the initiating events are poorly defined. Here we uncover a fundamental role of commensal skin microbiota in this process and show that it is mediated by the recruitment and the activation of type I interferon (IFN)-producing plasmacytoid DC (pDC). Commensal bacteria colonizing skin wounds trigger activation of neutrophils to express the chemokine CXCL10, which recruits pDC and acts as an antimicrobial protein to kill exposed microbiota, leading to the formation of CXCL10–bacterial DNA complexes. These complexes and not complexes with host-derived DNA activate pDC to produce type I IFNs, which accelerate wound closure by triggering skin inflammation and early T cell–independent wound repair responses, mediated by macrophages and fibroblasts that produce major growth factors required for healing. These findings identify a key function of commensal microbiota in driving a central innate wound healing response of the skin.
DOI: 10.1038/s41590-020-0721-6
Source: https://www.nature.com/articles/s41590-020-0721-6
Nature Immunology:《自然—免疫学》,创刊于2000年。隶属于施普林格·自然出版集团,最新IF:31.25
官方网址:https://www.nature.com/ni/
投稿链接:https://mts-ni.nature.com/cgi-bin/main.plex
本期文章:《自然—免疫学》:Online/在线发表