小柯机器人

共生微生物菌群可促进皮肤伤口修复
2020-07-16 15:01

瑞士洛桑大学Michel Gilliet研究团队发现,共生的皮肤微生物菌群能够在受伤的皮肤上触发I型干扰素依赖性先天性修复反应。该项研究成果发表于2020年7月13日在线发表在《自然—免疫学》杂志上。

据研究人员介绍,皮肤伤口通过炎症和组织修复的协同作用而愈合,但是起始事件的定义仍不明确。
 
研究人员发现了共生皮肤微生物群在此过程中的基本作用,并表明它是由招募和激活产生I型干扰素(IFN)的浆细胞样DC(pDC)介导的。侵染皮肤伤口的共生细菌触发嗜中性粒细胞的活化,从而表达趋化因子CXCL10,后者吸收pDC并充当杀灭微生物群体的抗菌蛋白,进而导致形成CXCL10-细菌DNA复合物。
 
这些复合物(而非与宿主衍生的DNA的复合物)能够激活pDC来产生I型IFN,从而通过触发皮肤炎症和早期T细胞依赖的伤口修复反应(由巨噬细胞和成纤维细胞介导,产生愈合所需的主要生长因子)来加速伤口闭合。这些发现确定了共生菌群在促进皮肤关键先天性伤口愈合反应中的核心功能。
 
附:英文原文
 
Title: The commensal skin microbiota triggers type I IFN–dependent innate repair responses in injured skin

Author: Jeremy Di Domizio, Cyrine Belkhodja, Pauline Chenuet, Anissa Fries, Timothy Murray, Paula Marcos Mondjar, Olivier Demaria, Curdin Conrad, Bernhard Homey, Sabine Werner, Daniel E. Speiser, Bernhard Ryffel, Michel Gilliet

Issue&Volume: 2020-07-13

Abstract: Skin wounds heal by coordinated induction of inflammation and tissue repair, but the initiating events are poorly defined. Here we uncover a fundamental role of commensal skin microbiota in this process and show that it is mediated by the recruitment and the activation of type I interferon (IFN)-producing plasmacytoid DC (pDC). Commensal bacteria colonizing skin wounds trigger activation of neutrophils to express the chemokine CXCL10, which recruits pDC and acts as an antimicrobial protein to kill exposed microbiota, leading to the formation of CXCL10–bacterial DNA complexes. These complexes and not complexes with host-derived DNA activate pDC to produce type I IFNs, which accelerate wound closure by triggering skin inflammation and early T cell–independent wound repair responses, mediated by macrophages and fibroblasts that produce major growth factors required for healing. These findings identify a key function of commensal microbiota in driving a central innate wound healing response of the skin.

DOI: 10.1038/s41590-020-0721-6

Source: https://www.nature.com/articles/s41590-020-0721-6

Nature Immunology:《自然—免疫学》,创刊于2000年。隶属于施普林格·自然出版集团,最新IF:31.25
官方网址:https://www.nature.com/ni/
投稿链接:https://mts-ni.nature.com/cgi-bin/main.plex


本期文章:《自然—免疫学》:Online/在线发表

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