小柯机器人

美国德克萨斯大学西南医学中心Nan Yan研究团队发现，干扰素非依赖性STING活性介导抗病毒反应和肿瘤免疫逃逸。2020年7月7日，《免疫》在线发表了这一成果。

Title: Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion

Author: Jianjun Wu, Nicole Dobbs, Kun Yang, Nan Yan

Issue&Volume: 2020-07-07

Abstract: Type I interferon (IFN) response is commonly recognized as the main signaling activityof STING. Here, we generate the Sting1S365A/S365A mutant mouse that precisely ablates IFN-dependent activities while preserving IFN-independentactivities of STING. StingS365A/S365A mice protect against HSV-1 infection, despite lacking the STING-mediated IFN response.This challenges the prevailing view and suggests that STING controls HSV-1 infectionthrough IFN-independent activities. Transcriptomic analysis reveals widespread IFN-independentactivities of STING in macrophages and T cells, and STING activities in T cells arepredominantly IFN independent. In mouse tumor models, T cells in the tumor experiencesubstantial cell death that is in part mediated by IFN-independent activities of STING.We found that the tumor induces STING-mediated cell death in T cells to evade immunecontrol. Our data demonstrate that mammalian STING possesses widespread IFN-independentactivities that are important for restricting HSV-1 infection, tumor immune evasionand likely also adaptive immunity.

DOI: 10.1016/j.immuni.2020.06.009

Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30264-8

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