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科学家制造出能够孕育兔子的组织工程化子宫
2020-06-30 21:22

美国维克森林大学医学院Anthony Atala研究组开发出能够支持兔子活产的组织工程化子宫。该研究于2020年6月29日在线发表于《自然—生物技术》。

研究人员使用植入自体细胞的可生物降解聚合物支架来恢复了兔子的子宫结构和功能。兔子经子宫次全切除,并用自体细胞接种的构建体、以及无种子的支架或缝合重建。
 
植入后6个月,只有接种细胞的工程子宫发育出天然的组织样结构,包括有组织的腔/腺上皮、基质、血管化粘膜和两层子宫肌层。只有具有细胞结构的兔子在子宫的重建部分可以正常怀孕(十分之四),并支持胎儿发育至足月和活产。随着进一步的发展,这种方法可以为子宫不孕症提供再生医学解决方案。
 
据了解,生物工程化的子宫组织可以为患有子宫不孕症的妇女提供治疗选择。在大型动物模型中,只有异种组织移植物才能证明子宫的重建。
 
附:英文原文

Title: A tissue-engineered uterus supports live births in rabbits

Author: Renata S. Magalhaes, J. Koudy Williams, Kyung W. Yoo, James J. Yoo, Anthony Atala

Issue&Volume: 2020-06-29

Abstract: Bioengineered uterine tissue could provide a treatment option for women with uterine factor infertility. In large animal models, reconstruction of the uterus has been demonstrated only with xenogeneic tissue grafts. Here we use biodegradable polymer scaffolds seeded with autologous cells to restore uterine structure and function in rabbits. Rabbits underwent a subtotal uterine excision and were reconstructed with autologous cell-seeded constructs, with nonseeded scaffolds or by suturing. At 6months postimplantation, only the cell-seeded engineered uteri developed native tissue-like structures, including organized luminal/glandular epithelium, stroma, vascularized mucosa and two-layered myometrium. Only rabbits with cell-seeded constructs had normal pregnancies (four in ten) in the reconstructed segment of the uterus and supported fetal development to term and live birth. With further development, this approach may provide a regenerative medicine solution to uterine factor infertility.

DOI: 10.1038/s41587-020-0547-7

Source: https://www.nature.com/articles/s41587-020-0547-7

Nature Biotechnology:《自然—生物技术》,创刊于1996年。隶属于施普林格·自然出版集团,最新IF:31.864
官方网址:https://www.nature.com/nbt/
投稿链接:https://mts-nbt.nature.com/cgi-bin/main.plex


本期文章:《自然—生物技术》:Online/在线发表

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