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研究揭示人类怀孕过程中的代谢动态变化
2020-06-28 14:35

丹麦哥本哈根大学Mads Melbye、美国斯坦福大学Michael Snyder等研究人员合作揭示了人类怀孕过程中的代谢动态变化。该研究于2020年6月25日发表于《细胞》。

为了定义健康怀孕期间代谢物的高分辨率时间分布,研究人员分析了来自30位孕妇的784个每周血液样本的非靶向代谢组。结果揭示了广泛的变化:怀孕期间4,995个代谢特征(总共9,651个)、460个带注释的化合物(总共687个)和34条人类代谢途径(总共48个)发生了显著变化。
 
使用线性模型,研究人员建立了具有五个代谢物的代谢时钟,并高度符合超声检测的胎龄(R=0.92)。此外,两到三个代谢物可以识别何时发生分娩(分娩时间在两周、四周和八周内,AUROC≥0.85)。这项研究展现了人类妊娠代谢组的每周特征,并为了解妊娠提供了高分辨率的图谱。
 
据介绍,怀孕期间的代谢是一个动态且精确编程的过程,其失败会给母亲和胎儿带来毁灭性后果。
 
附:英文原文

Title: Metabolic Dynamics and Prediction of Gestational Age and Time to Delivery in Pregnant Women

Author: Liang Liang, Marie-Louise Hee Rasmussen, Brian Piening, Xiaotao Shen, Songjie Chen, Hannes Rst, John K. Snyder, Robert Tibshirani, Line Skotte, Norman CY. Lee, Kévin Contrepois, Bjarke Feenstra, Hanyah Zackriah, Michael Snyder, Mads Melbye

Issue&Volume: 2020/06/25

Abstract: Metabolism during pregnancy is a dynamic and precisely programmed process, the failure of which can bring devastating consequences to the mother and fetus. To define a high-resolution temporal profile of metabolites during healthy pregnancy, we analyzed the untargeted metabolome of 784 weekly blood samples from 30 pregnant women. Broad changes and a highly choreographed profile were revealed: 4,995 metabolic features (of 9,651 total), 460 annotated compounds (of 687 total), and 34 human metabolic pathways (of 48 total) were significantly changed during pregnancy. Using linear models, we built a metabolic clock with five metabolites that time gestational age in high accordance with ultrasound (R = 0.92). Furthermore, two to three metabolites can identify when labor occurs (time to delivery within two, four, and eight weeks, AUROC ≥ 0.85). Our study represents a weekly characterization of the human pregnancy metabolome, providing a high-resolution landscape for understanding pregnancy with potential clinical utilities.

DOI: 10.1016/j.cell.2020.05.002

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)30564-X

Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216
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本期文章:《细胞》:Volume 181 Issue 7

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