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外周诱导的脑驻留记忆CD8 + T细胞保护中枢神经系统免受感染
2020-06-23 15:10

美国爱荷华大学John T. Harty研究组的最新研究发现,外周组织诱导的脑驻留记忆CD8 + T细胞介导了针对中枢神经系统(CNS)感染的保护。2020年6月22日,国际学术期刊《自然-免疫学》发表了这一成果。

研究人员发现外周感染会在大脑中产生具有独特TRM特性的抗原特异性CD8 +记忆T细胞。循环和血管周围记忆T细胞耗竭后,该脑特性得以富集;通过活体成像研究人员揭示了脑TRM细胞的监视特性。值得注意的是,在脑部感染后,外周诱导的脑TRM细胞快速激活,增强了细胞因子的产生以及介导了保护作用。这些数据表明,外周免疫可以产生脑TRM细胞,并揭示了T细胞作为对抗CNS感染和神经系统疾病治疗的潜在用途。

据了解,普遍认为CNS具有免疫特权。然而,最近的研究揭示了外周免疫系统和中枢神经系统在调控感染和组织稳态方面的相互作用。脑部感染后,CNS中会产生组织驻留记忆(TRM)CD8 + T细胞,但尚不清楚是否需要感染CNS才能产生脑TRM细胞。

附:英文原文

Title: Peripherally induced brain tissue–resident memory CD8 + T cells mediate protection against CNS infection

Author: Stina L. Urban, Isaac J. Jensen, Qiang Shan, Lecia L. Pewe, Hai-Hui Xue, Vladimir P. Badovinac, John T. Harty

Issue&Volume: 2020-06-22

Abstract: The central nervous system (CNS) is classically viewed as immune-privileged; however, recent advances highlight interactions between the peripheral immune system and CNS in controlling infections and tissue homeostasis. Tissue-resident memory (TRM) CD8+ T cells in the CNS are generated after brain infections, but it is unknown whether CNS infection is required to generate brain TRM cells. We show that peripheral infections generate antigen-specific CD8+ memory T cells in the brain that adopt a unique TRM signature. Upon depletion of circulating and perivascular memory T cells, this brain signature was enriched and the surveilling properties of brain TRM cells was revealed by intravital imaging. Notably, peripherally induced brain TRM cells showed evidence of rapid activation and enhanced cytokine production and mediated protection after brain infections. These data reveal that peripheral immunizations can generate brain TRM cells and will guide potential use of T cells as therapeutic strategies against CNS infections and neurological diseases.

DOI: 10.1038/s41590-020-0711-8

Source: https://www.nature.com/articles/s41590-020-0711-8

Nature Immunology:《自然—免疫学》,创刊于2000年。隶属于施普林格·自然出版集团,最新IF:31.25
官方网址:https://www.nature.com/ni/
投稿链接:https://mts-ni.nature.com/cgi-bin/main.plex


本期文章:《自然—免疫学》:Online/在线发表

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