英国伦敦大学学院G. Elliott Wimmer研究团队取得最新进展。他们发现情景记忆检索成功与事件内容的快速重放有关。相关论文2020年6月8日发表于《自然-神经科学》。
他们研究了首次经历的、无重复的、独特多组成40-80-s事件参与者。一天后，他们在进行脑磁图检查时，提示并检索这些事件。通过解码各个事件元素，他们发现事件元素的顺序重放支持逐次成功检索，其时间压缩因子> 60。支持重放的重放方向（向后还是向前），取决于任务目标是检索分别位于检索线索之后还是之前的事件元素。在表现非常出色的参与者中，这种顺序重放较弱，而在这些参与者中，他们发现了同时进行簇状再激活的证据。
他们的结果表明，记忆介导的决策受快速重放机制的支持，该机制可以根据任务目标灵活地改变方向。
研究人员表示，检索日常经历是告知人们未来决策的基础。支持这种记忆检索的细粒神经生理机制在很大程度上是未知的。
附：英文原文
Title: Episodic memory retrieval success is associated with rapid replay of episode content
Author: G. Elliott Wimmer, Yunzhe Liu, Nea Vehar, Timothy E. J. Behrens, Raymond J. Dolan
Issue&Volume: 2020-06-08
Abstract: Retrieval of everyday experiences is fundamental for informing our future decisions. The fine-grained neurophysiological mechanisms that support such memory retrieval are largely unknown. We studied participants who first experienced, without repetition, unique multicomponent 40–80-s episodes. One day later, they engaged in cued retrieval of these episodes while undergoing magnetoencephalography. By decoding individual episode elements, we found that trial-by-trial successful retrieval was supported by the sequential replay of episode elements, with a temporal compression factor of >60. The direction of replay supporting retrieval, either backward or forward, depended on whether the task goal was to retrieve elements of an episode that followed or preceded, respectively, a retrieval cue. This sequential replay was weaker in very-high-performing participants, in whom instead we found evidence for simultaneous clustered reactivation. Our results demonstrate that memory-mediated decisions are supported by a rapid replay mechanism that can flexibly shift in direction in response to task goals.
DOI: 10.1038/s41593-020-0649-z
Source: https://www.nature.com/articles/s41593-020-0649-z
Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex
本期文章：《自然—神经科学》：Online/在线发表
