清华大学张林琦、王新泉、国家感染性疾病临床医学研究中心张政等研究人员合作报道了新冠病毒（SARS-CoV-2）引发的人源中和抗体。相关论文于2020年5月26日在线发表于《自然》杂志。
研究人员报告了来自8个SARS-CoV-2感染个体中单个B细胞的206个受体结合域（RBD）特异性单克隆抗体的分离和表征。研究人员鉴定出具有有效中和活性的SARS-CoV-2抗体，这些抗体与ACE2的RBD结合竞争能力相关。
出人意料的是，抗SARS-CoV-2抗体和受感染者血浆均未与SARS-CoV或MERS-CoV RBD交叉反应，尽管发现了抗SARS-CoV-2抗体与其三聚体突刺蛋白存在实质性交叉反应性。与RBD结合的抗体晶体结构分析显示，位阻可抑制病毒与ACE2的结合，从而阻止病毒进入。这些发现表明抗RBD抗体是病毒物种特异性抑制剂。这些鉴定的抗体可能是SARS-CoV-2临床干预措施的候选抗体。
当前爆发的冠状病毒SARS-CoV-2大流行造成全球卫生紧急情况，目前急需采取干预措施。SARS-CoV-2进入靶细胞取决于病毒突刺蛋白的受体结合域（RBD）与ACE2细胞受体之间的结合。
附：英文原文
Title: Human neutralizing antibodies elicited by SARS-CoV-2 infection
Author: Bin Ju, Qi Zhang, Jiwan Ge, Ruoke Wang, Jing Sun, Xiangyang Ge, Jiazhen Yu, Sisi Shan, Bing Zhou, Shuo Song, Xian Tang, Jinfang Yu, Jun Lan, Jing Yuan, Haiyan Wang, Juanjuan Zhao, Shuye Zhang, Youchun Wang, Xuanling Shi, Lei Liu, Jincun Zhao, Xinquan Wang, Zheng Zhang, Linqi Zhang
Issue&Volume: 2020-05-26
Abstract: The emerging coronavirus SARS-CoV-2 pandemic presents a global health emergency in urgent need of interventions1–3. SARS-CoV-2 entry into the target cells depends on binding between the receptor-binding domain (RBD) of the viral Spike protein and the ACE2 cell receptor2,4–6. Here, we report the isolation and characterization of 206 RBD-specific monoclonal antibodies derived from single B cells of eight SARS-CoV-2 infected individuals. We identified antibodies with potent anti-SARS-CoV-2 neutralization activity that correlates with their competitive capacity with ACE2 for RBD binding. Surprisingly, neither the anti-SARS-CoV-2 antibodies nor the infected plasma cross-reacted with SARS-CoV or MERS-CoV RBDs, although substantial plasma cross-reactivity to their trimeric Spike proteins was found. Crystal structure analysis of RBD-bound antibody revealed steric hindrance that inhibits viral engagement with ACE2 and thereby blocks viral entry. These findings suggest that anti-RBD antibodies are viral species-specific inhibitors. The antibodies identified here may be candidates for the development of SARS-CoV-2 clinical interventions.
DOI: 10.1038/s41586-020-2380-z
Source: https://www.nature.com/articles/s41586-020-2380-z
Nature：《自然》，创刊于1869年。隶属于施普林格·自然出版集团，最新IF：69.504
官方网址：http://www.nature.com/
投稿链接：http://www.nature.com/authors/submit_manuscript.html
本期文章：《自然》：Online/在线发表
