美国贝勒医学院Jeffrey C. Magee、霍华德休斯医学研究所Nelson Spruston等研究人员合作观察到了海马体中情景相关感知响应的膜电位动态。2020年5月25日,《自然—神经科学》杂志在线发表了这一最新研究成果。
Title: Membrane potential dynamics underlying context-dependent sensory responses in the hippocampus
Author: Xinyu Zhao, Yingxue Wang, Nelson Spruston, Jeffrey C. Magee
Issue&Volume: 2020-05-25
Abstract: As animals navigate, they must identify features within context. In the mammalian brain, the hippocampus has the ability to separately encode different environmental contexts, even when they share some prominent features. To do so, neurons respond to sensory features in a context-dependent manner; however, it is not known how this encoding emerges. To examine this, we performed electrical recordings in the hippocampus as mice navigated in two distinct virtual environments. In CA1, both synaptic input to single neurons and population activity strongly tracked visual cues in one environment, whereas responses were almost completely absent when the same cue was presented in a second environment. A very similar, highly context-dependent pattern of cue-driven spiking was also observed in CA3. These results indicate that CA1 inherits a complex spatial code from upstream regions, including CA3, that have already computed a context-dependent representation of environmental features.
DOI: 10.1038/s41593-020-0646-2
Source: https://www.nature.com/articles/s41593-020-0646-2
Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:87.241
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex
本期文章:《自然—医学》:Online/在线发表