小柯机器人

科学家揭示海马体中情景相关感知响应的膜电位动态
2020-05-28 18:20

美国贝勒医学院Jeffrey C. Magee、霍华德休斯医学研究所Nelson Spruston等研究人员合作观察到了海马体中情景相关感知响应的膜电位动态。2020年5月25日,《自然—神经科学》杂志在线发表了这一最新研究成果。

研究人员表示,当动物确定方位时,它们必须在环境中识别特征。在哺乳动物的大脑中,海马体能够分别编码不同的环境背景,即使它们具有一些相同的主要特征。为此,神经元以环境有关的方式对感觉特征作出反应。但是,目前尚不清楚这种编码如何出现。
 
为了回答这一问题,当小鼠在两个不同的虚拟环境中找寻方向时,研究人员在海马体中进行了电记录。在CA1区中,单个神经元的突触输入和群体活动都强烈跟踪了一个环境中的视觉提示,而在第二个环境中出现相同提示时,则几乎完全没有响应。在CA3区中也观察到了非常类似的、高度依赖情景的模式。这些结果表明,CA1区从上游区域(包括CA3区)继承了复杂的空间编码,而这些编码已经计算了情景相关的环境特征。
 
附:英文原文

Title: Membrane potential dynamics underlying context-dependent sensory responses in the hippocampus

Author: Xinyu Zhao, Yingxue Wang, Nelson Spruston, Jeffrey C. Magee

Issue&Volume: 2020-05-25

Abstract: As animals navigate, they must identify features within context. In the mammalian brain, the hippocampus has the ability to separately encode different environmental contexts, even when they share some prominent features. To do so, neurons respond to sensory features in a context-dependent manner; however, it is not known how this encoding emerges. To examine this, we performed electrical recordings in the hippocampus as mice navigated in two distinct virtual environments. In CA1, both synaptic input to single neurons and population activity strongly tracked visual cues in one environment, whereas responses were almost completely absent when the same cue was presented in a second environment. A very similar, highly context-dependent pattern of cue-driven spiking was also observed in CA3. These results indicate that CA1 inherits a complex spatial code from upstream regions, including CA3, that have already computed a context-dependent representation of environmental features.

DOI: 10.1038/s41593-020-0646-2

Source: https://www.nature.com/articles/s41593-020-0646-2

Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:87.241
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex


本期文章:《自然—医学》:Online/在线发表

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