小柯机器人

美国埃默里大学医学院的Thomas S. Wingo、Allan I. Levey、Nicholas T. Seyfried、Aliza P. Wingo等研究人员，合作揭示了脑动脉粥样硬化和阿尔茨海默氏病对人脑的共同蛋白质组学作用。相关论文于2020年5月18日在线发表在《自然—神经科学》杂志上。

Title: Shared proteomic effects of cerebral atherosclerosis and Alzheimer’s disease on the human brain

Author: Aliza P. Wingo, Wen Fan, Duc M. Duong, Ekaterina S. Gerasimov, Eric B. Dammer, Yue Liu, Nadia V. Harerimana, Bartholomew White, Madhav Thambisetty, Juan C. Troncoso, Namhee Kim, Julie A. Schneider, Ihab M. Hajjar, James J. Lah, David A. Bennett, Nicholas T. Seyfried, Allan I. Levey, Thomas S. Wingo

Issue&Volume: 2020-05-18

Abstract: Cerebral atherosclerosis contributes to dementia via unclear processes. We performed proteomic sequencing of dorsolateral prefrontal cortex in 438 older individuals and found associations between cerebral atherosclerosis and reduced synaptic signaling and between RNA splicing and increased oligodendrocyte development and myelination. Consistently, single-cell RNA sequencing showed cerebral atherosclerosis associated with higher oligodendrocyte abundance. A subset of proteins and modules associated with cerebral atherosclerosis was also associated with Alzheimer’s disease, suggesting shared mechanisms.

DOI: 10.1038/s41593-020-0635-5

Source: https://www.nature.com/articles/s41593-020-0635-5

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex