国家感染性疾病临床医学研究中心(南方科技大学第二附属医院/深圳市第三人民医院)张政、复旦大学附属上海市公共卫生中心章树业、以色列魏兹曼研究所Ido Amit以及深圳市第三人民医院刘磊等研究人员,合作绘制了COVID-19患者支气管肺泡免疫细胞的单细胞图谱。这一研究成果于2020年5月11日在线发表在国际学术期刊《自然—医学》上。
Title: Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
Author: Mingfeng Liao, Yang Liu, Jing Yuan, Yanling Wen, Gang Xu, Juanjuan Zhao, Lin Cheng, Jinxiu Li, Xin Wang, Fuxiang Wang, Lei Liu, Ido Amit, Shuye Zhang, Zheng Zhang
Issue&Volume: 2020-05-12
Abstract: Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
DOI: 10.1038/s41591-020-0901-9
Source: https://www.nature.com/articles/s41591-020-0901-9
Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:87.241
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex
本期文章:《自然—医学》:Online/在线发表