小柯机器人

美国南加州大学Pinghui Feng研究组取得新进展，他们的最新工作发现，脱酰胺使RelA从介导炎症转变为有氧糖酵解。该研究于2020年4月22日在线发表于《细胞—代谢》。

Title: Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis

Author: Jun Zhao, Mao Tian, Shu Zhang, Alireza Delfarah, Ruoyun Gao, Youliang Rao, Ali Can Savas, Anjie Lu, Larissa Bubb, Xiao Lei, Rosa Moshirian, Wenjie Zhu, Cheng Peng, Taijiao Jiang, Lin Chen, Nicholas A. Graham, Pinghui Feng

Issue&Volume: 2020-04-22

Abstract: Cell proliferation and inflammation are two metabolically demanding biological processes.How these competing processes are selectively executed in the same cell remains unknown.Here, we report that the enzyme carbamoyl-phosphate synthetase, aspartyl transcarbamoylase,and dihydroorotase (CAD) deamidates the RelA subunit of NF-κB in cancer cells to promoteaerobic glycolysis and fuel cell proliferation in tumorigenesis. This post-translationalmodification switches RelA function from mediating the expression of NF-κB-responsivegenes to that of glycolytic enzymes, thus shunting the cell’s inflammatory responseto aerobic glycolysis. Further, we profiled diverse human cancer cell lines and foundthat high CAD expression and a subset of RELA mutations correlated with RelA deamidation. And by use of inhibitors of key glycolyticenzymes, we validated the pivotal role of RelA deamidation in tumorigenesis of cancercell lines. This work illuminates a mechanism by which protein deamidation selectivelyspecifies gene expression and consequent biological processes.

DOI: 10.1016/j.cmet.2020.04.006

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30188-1

Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
官方网址：https://www.cell.com/cell-metabolism/home
投稿链接：https://www.editorialmanager.com/cell-metabolism/default.aspx