小柯机器人

美国芝加哥大学Peter A. Savage研究团队的一项最新表明，Eomes是自特异性记忆表型CD8⁺T细胞的胸腺前体细胞标志。相关论文于2020年4月13日在线发表在《自然—免疫学》杂志上。

Title: Eomes identifies thymic precursors of self-specific memory-phenotype CD8 + T cells

Author: Christine H. Miller, David E. J. Klawon, Sharon Zeng, Victoria Lee, Nicholas D. Socci, Peter A. Savage

Issue&Volume: 2020-04-13

Abstract: Unprimed mice harbor a substantial population of ‘memory-phenotype’ CD8+ T cells (CD8-MP cells) that exhibit hallmarks of activation and innate-like functional properties. Due to the lack of faithful markers to distinguish CD8-MP cells from bona fide CD8+ memory T cells, the developmental origins and antigen specificities of CD8-MP cells remain incompletely defined. Using deep T cell antigen receptor (TCR) sequencing, we found that the TCRs expressed by CD8-MP cells are highly recurrent and distinct from the TCRs expressed by naive-phenotype CD8+ T cells. CD8-MP clones exhibited reactivity to widely expressed self-ligands. T cell precursors expressing CD8-MP TCRs showed upregulation of the transcription factor Eomes during maturation in the thymus, prior to induction of the full memory phenotype, which is suggestive of a unique program triggered by recognition of self-ligands. Moreover, CD8-MP cells infiltrate oncogene-driven prostate tumors and express high densities of PD-1, which suggests potential roles in antitumor immunity and the response to immunotherapy.

DOI: 10.1038/s41590-020-0653-1

Source: https://www.nature.com/articles/s41590-020-0653-1

Nature Immunology：《自然—免疫学》，创刊于2000年。隶属于施普林格·自然出版集团，最新IF：31.25
官方网址：https://www.nature.com/ni/
投稿链接：https://mts-ni.nature.com/cgi-bin/main.plex