2020年4月1日,《免疫》杂志在线发表了日本理化学研究所Hiroshi Ohno、Naoko Satoh-Takayama等研究人员的合作成果。他们的最新研究表明,胃细菌诱导的2型先天淋巴样细胞通过产生IgA来提供免疫保护。
Title: Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA
Author: Naoko Satoh-Takayama, Tamotsu Kato, Yasutaka Motomura, Tomoko Kageyama, Naoko Taguchi-Atarashi, Ryo Kinoshita-Daitoku, Eisuke Kuroda, James P. Di Santo, Hitomi Mimuro, Kazuyo Moro, Hiroshi Ohno
Issue&Volume: 2020-04-01
Abstract: The intestinal microbiota shapes and directs immune development locally and systemically,but little is known about whether commensal microbes in the stomach can impact theirimmunological microenvironment. Here, we report that group 2 innate lymphoid cells(ILC2s) were the predominant ILC subset in the stomach and show that their homeostasisand effector functions were regulated by local commensal communities. Microbes elicitedinterleukin-7 (IL-7) and IL-33 production in the stomach, which in turn triggeredthe propagation and activation of ILC2. Stomach ILC2s were also rapidly induced followinginfection with Helicobacter pylori. ILC2-derived IL-5 resulted in the production of IgA, which coated stomach bacteriain both specific pathogen-free (SPF) and H. pylori-infected mice. Our study thus identifies ILC2-dependent IgA response that is regulatedby the commensal microbiota, which is implicated in stomach protection by eliminatingIgA-coated bacteria including pathogenic H. pylori.
DOI: 10.1016/j.immuni.2020.03.002
Source: https://www.cell.com/immunity/fulltext/S1074-7613(20)30090-X
Immunity:《免疫》,创刊于1994年。隶属于细胞出版社,最新IF:43.474
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本期文章:《免疫》:Online/在线发表