小柯机器人

美国西北大学John A. Rogers和Jong Yoon Lee以及美国芝加哥安·罗伯特·H·卢里儿童医院Debra E. Weese-Mayer研究组合作取得研究新进展。他们开发出皮肤界面生物传感器可用于新生儿和儿科重症监护病房（分别为NICU和PICU）的高级无线生理监测。这一研究成果发表在2020年3月11日出版的《自然-医学》杂志上。

他们提供了一种无线、非侵入性技术，不仅可以提供与现有临床标准相当的心率、呼吸频率、温度和血液氧合水平的测定，而且还提供了一系列重要的附加功能，并在NICU和PICU中得到了先导临床研究数据的支持。这些新的方式包括跟踪运动和身体朝向，量化皮肤对皮肤护理的生理益处，捕获心脏活动的声学特征，记录与哭声的音调和时间特征相关的声音生物标志物，以及监测收缩压的可靠替代物。这些平台有可能大大提高新生儿和儿科重症监护的质量。

据悉， NICU和PICU的标准临床护理包括使用附着在皮肤上的硬接线设备对生命体征进行连续监测，在某些情况下，可以将基于导管的压力传感器插入到患者动脉。这些系统具有引起医源性皮肤损伤，使临床护理复杂化和阻碍父母与孩子之间皮肤接触的风险。

附：英文原文

Title: Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units

Author: Ha Uk Chung, Alina Y. Rwei, Aurlie Hourlier-Fargette, Shuai Xu, KunHyuck Lee, Emma C. Dunne, Zhaoqian Xie, Claire Liu, Andrea Carlini, Dong Hyun Kim, Dennis Ryu, Elena Kulikova, Jingyue Cao, Ian C. Odland, Kelsey B. Fields, Brad Hopkins, Anthony Banks, Christopher Ogle, Dominic Grande, Jun Bin Park, Jongwon Kim, Masahiro Irie, Hokyung Jang, JooHee Lee, Yerim Park, Jungwoo Kim, Han Heul Jo, Hyoungjo Hahm, Raudel Avila, Yeshou Xu, Myeong Namkoong, Jean Won Kwak, Emily Suen, Max A. Paulus, Robin J. Kim, Blake V. Parsons, Kelia A. Human, Seung Sik Kim, Manish Patel, William Reuther, Hyun Soo Kim, Sung Hoon Lee, John D. Leedle, Yeojeong Yun, Sarah Rigali, Taeyoung Son, Inhwa Jung, Hany Arafa, Vinaya R. Soundararajan, Ayelet Ollech, Avani Shukla, Allison Bradley, Molly Schau, Casey M. Rand, Lauren E. Marsillio, Zena L. Harris

Issue&Volume: 2020-03-11

Abstract: Standard clinical care in neonatal and pediatric intensive-care units (NICUs and PICUs, respectively) involves continuous monitoring of vital signs with hard-wired devices that adhere to the skin and, in certain instances, can involve catheter-based pressure sensors inserted into the arteries. These systems entail risks of causing iatrogenic skin injuries, complicating clinical care and impeding skin-to-skin contact between parent and child. Here we present a wireless, non-invasive technology that not only offers measurement equivalency to existing clinical standards for heart rate, respiration rate, temperature and blood oxygenation, but also provides a range of important additional features, as supported by data from pilot clinical studies in both the NICU and PICU. These new modalities include tracking movements and body orientation, quantifying the physiological benefits of skin-to-skin care, capturing acoustic signatures of cardiac activity, recording vocal biomarkers associated with tonality and temporal characteristics of crying and monitoring a reliable surrogate for systolic blood pressure. These platforms have the potential to substantially enhance the quality of neonatal and pediatric critical care.

DOI: 10.1038/s41591-020-0792-9

Source: https://www.nature.com/articles/s41591-020-0792-9

Nature Medicine：《自然—医学》，创刊于1995年。隶属于施普林格·自然出版集团，最新IF：87.241
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