小柯机器人

近日，美国西奈山伊坎医学院Hongyan Zou、Roland H. Friedel等研究人员合作发现，小胶质细胞和巨噬细胞通过Plexin-B2促进脊髓损伤后的包围、伤口收缩和恢复。该项研究成果于2020年2月28日在线发表在《自然—神经科学》杂志上。

Title: Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

Author: Xiang Zhou, Shalaka Wahane, Marie-Sophie Friedl, Michael Kluge, Caroline C. Friedel, Kleopatra Avrampou, Venetia Zachariou, Lei Guo, Bin Zhang, Xijing He, Roland H. Friedel, Hongyan Zou

Issue&Volume: 2020-02-28

Abstract: Tissue repair after spinal cord injury requires the mobilization of immune and glial cells to form a protective barrier that seals the wound and facilitates debris clearing, inflammatory containment and matrix compaction. This process involves corralling, wherein phagocytic immune cells become confined to the necrotic core, which is surrounded by an astrocytic border. Here we elucidate a temporally distinct gene signature in injury-activated microglia and macrophages (IAMs) that engages axon guidance pathways. Plexin-B2 is upregulated in IAMs and is required for motor sensory recovery after spinal cord injury. Plexin-B2 deletion in myeloid cells impairs corralling, leading to diffuse tissue damage, inflammatory spillover and hampered axon regeneration. Corralling begins early and requires Plexin-B2 in both microglia and macrophages. Mechanistically, Plexin-B2 promotes microglia motility, steers IAMs away from colliding cells and facilitates matrix compaction. Our data therefore establish Plexin-B2 as an important link that integrates biochemical cues and physical interactions of IAMs with the injury microenvironment during wound healing.

DOI: 10.1038/s41593-020-0597-7

Source: https://www.nature.com/articles/s41593-020-0597-7

Nature Neuroscience：《自然—神经科学》，创刊于1998年。隶属于施普林格·自然出版集团，最新IF：28.771
官方网址：https://www.nature.com/neuro/
投稿链接：https://mts-nn.nature.com/cgi-bin/main.plex