美国威斯康辛大学-麦迪逊分校Darcie L. Moore研究组的最新研究发现神经干细胞脱离静态过程中，在聚集体处波形蛋白协调蛋白质周转率。相关论文在线发表在2020年2月27日出版的《细胞-干细胞》杂志上。
研究人员证明成年神经干细胞（NSCs）利用聚集体恢复破坏的蛋白稳态，并揭示了在蛋白稳态过程中，中间丝波形蛋白作为蛋白酶体到聚集体空间协调因子的新功能。在缺乏波形蛋白的情况下，NSC具有降低离开静止态的能力，而离开静止态需要NSC清除聚集的蛋白质；并且研究还证明神经发生和增殖的早期年龄依赖性下降。综上所述，这些数据揭示了波形蛋白聚集体在静态NSC激活过程中调节蛋白质稳态的重要作用。
据了解，在整个生命过程中维持健康的蛋白质组对于体细胞的干细胞功能至关重要，但是尚不清楚干细胞如何应对受损或聚集蛋白增加。
附：英文原文
Title: Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit
Author: Christopher S. Morrow, Tiaira J. Porter, Nan Xu, Zachary P. Arndt, Kayla Ako-Asare, Helen J. Heo, Elizabeth A.N. Thompson, Darcie L. Moore
Issue&Volume: 2020-02-27
Abstract: Maintaining a healthy proteome throughout life is critical for proper somatic stemcell function, but the complexities of the stem cell response to increases in damagedor aggregated proteins remain unclear. Here we demonstrate that adult neural stemcells (NSCs) utilize aggresomes to recover from disrupted proteostasis and describea novel function for the intermediate filament vimentin in proteostasis as a spatialcoordinator of proteasomes to the aggresome. In the absence of vimentin, NSCs havea reduced capacity to exit quiescence, a time when NSCs are required to clear a waveof aggregated proteins, and demonstrate an early age-dependent decline in proliferationand neurogenesis. Taken together, these data reveal a significant role of vimentinand aggresomes in the regulation of proteostasis during quiescent NSC activation.
DOI: 10.1016/j.stem.2020.01.018
Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30018-7
Cell Stem Cell：《细胞—干细胞》，创刊于2007年。隶属于细胞出版社，最新IF：25.269
官方网址：https://www.cell.com/cell-stem-cell/home
投稿链接：https://www.editorialmanager.com/cell-stem-cell/default.aspx
本期文章：《细胞—干细胞》：Online/在线发表
