小柯机器人

近日，以色列魏茨曼科学研究所Ido Amit等研究人员讨论了开发下一代免疫疗法的单细胞基因组方法。这一论文2020年2月3日在线发表在国际学术期刊《自然—医学》上。

Title: Single-cell genomic approaches for developing the next generation of immunotherapies

Author: Ido Yofe, Rony Dahan, Ido Amit

Issue&Volume: 2020-02-03

Abstract: Recent progress in single-cell genomics urges its application in drug development, particularly of cancer immunotherapies. Current immunotherapy pipelines are focused on functional outcome and simple cellular and molecular readouts. A thorough mechanistic understanding of the cells and pathways targeted by immunotherapy agents is lacking, which limits the success rate of clinical trials. A large leap forward can be made if the immunotherapy target cells and pathways are characterized at high resolution before and after treatment, in clinical cohorts and model systems. This will enable rapid development of effective immunotherapies and data-driven design of synergistic drug combinations. In this Perspective, we discuss how emerging single-cell genomic technologies can serve as an engine for target identification and drug development.

DOI: 10.1038/s41591-019-0736-4

Source: https://www.nature.com/articles/s41591-019-0736-4

Nature Medicine：《自然—医学》，创刊于1995年。隶属于施普林格·自然出版集团，最新IF：87.241
官方网址：https://www.nature.com/nm/
投稿链接：https://mts-nmed.nature.com/cgi-bin/main.plex