美国密歇根大学Martin G. Myers Jr.、英国剑桥大学Clemence Blouet等研究人员合作发现,小鼠孤束核中的降钙素受体神经元通过非厌恶性饮食抑制调控能量平衡。这一研究成果2020年1月16日在线发表在国际学术期刊《细胞—代谢》上。
Title: Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding
Author: Wenwen Cheng, Ian Gonzalez, Warren Pan, Anthony H. Tsang, Jessica Adams, Ermelinda Ndoka, Desiree Gordian, Basma Khoury, Karen Roelofs, Simon S. Evers, Andrew MacKinnon, Shuangcheng Wu, Henriette Frikke-Schmidt, Jonathan N. Flak, James L. Trevaskis, Christopher J. Rhodes, So-ichiro Fukada, Randy J. Seeley, Darleen A. Sandoval, David P. Olson, Clemence Blouet, Martin G. Myers
Issue&Volume: January 16, 2020
Abstract: To understand hindbrain pathways involved in the control of food intake, we examinedroles for calcitonin receptor (CALCR)-containing neurons in the NTS. Ablation of NTSCalcr abrogated the long-term suppression of food intake, but not aversive responses, byCALCR agonists. Similarly, activating CalcrNTS neurons decreased food intake and body weight but (unlike neighboring CckNTS cells) failed to promote aversion, revealing that CalcrNTS neurons mediate a non-aversive suppression of food intake. While both CalcrNTS and CckNTS neurons decreased feeding via projections to the PBN, CckNTS cells activated aversive CGRPPBN cells while CalcrNTS cells activated distinct non-CGRP PBN cells. Hence, CalcrNTS cells suppress feeding via non-aversive, non-CGRP PBN targets. Additionally, silencingCalcrNTS cells blunted food intake suppression by gut peptides and nutrients, increasing foodintake and promoting obesity. Hence, CalcrNTS neurons define a hindbrain system that participates in physiological energy balanceand suppresses food intake without activating aversive systems.
DOI: 10.1016/j.cmet.2019.12.012
Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30677-1
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本期文章:《细胞—代谢》:Online/在线发表