小柯机器人

科学家综述cGAS-和RLR-如何调控核酸免疫
2019-12-10 14:35

美国哈佛医学院Sun Hur和瑞士联邦理工学院Andrea Ablasser研究组合作,综述了cGAS-和RLR-如何调控细胞对核酸的免疫。相关论文在线发表在2019年12月9日的《自然—免疫学》上。

来源于病原体的核酸是先天免疫的关键信号。尽管它们与宿主核酸有相似的结构,但是哺乳动物细胞已经进化出强大的先天免疫信号传导途径,用于检测胞浆核酸的种类,其中最突出的是cGAS–STING信号通路可以应答DNA以及RLR-MAVS信号通路对RNA的应答。最近的进展已经揭示了许多调节机制,这些调节机制对平衡核酸传感器的活性和维持整个细胞内稳态都至关重要。阐明维持细胞对胞质核酸传感器活性控制的各种机制,有利于人们理解疾病的病理学,同时,也提供了丰富且未知的潜在治疗靶点。本综述介绍了有关cGAS和RLR如何调节对细胞质DNA和RNA进行免疫的新研究。

附:英文原文

Title: Regulation of cGAS- and RLR-mediated immunity to nucleic acids

Author: Andrea Ablasser, Sun Hur

Issue&Volume: 2019-12-09

Abstract: Pathogen-derived nucleic acids are crucial signals for innate immunity. Despite the structural similarity between those and host nucleic acids, mammalian cells have been able to evolve powerful innate immune signaling pathways that originate from the detection of cytosolic nucleic acid species, one of the most prominent being the cGAS–STING pathway for DNA and the RLR–MAVS pathway for RNA, respectively. Recent advances have revealed a plethora of regulatory mechanisms that are crucial for balancing the activity of nucleic acid sensors for the maintenance of overall cellular homeostasis. Elucidation of the various mechanisms that enable cells to maintain control over the activity of cytosolic nucleic acid sensors has provided new insight into the pathology of human diseases and, at the same time, offers a rich and largely unexplored source for new therapeutic targets. This Review addresses the emerging literature on regulation of the sensing of cytosolic DNA and RNA via cGAS and RLRs.

DOI: 10.1038/s41590-019-0556-1

Source: https://www.nature.com/articles/s41590-019-0556-1

Nature Immunology:《自然—免疫学》,创刊于2000年。隶属于施普林格·自然出版集团,最新IF:23.53
官方网址:https://www.nature.com/ni/
投稿链接:https://mts-ni.nature.com/cgi-bin/main.plex


本期文章:《自然—免疫学》:Online/在线发表

分享到:

0