小柯机器人

科学家研发出基于DNA的新型储存材料
2019-12-10 15:00

瑞士联邦理工Robert N. Grass与以色列Erlich实验室Yaniv Erlich合作开发了一种信息存储结构,其能够用于创造具有嵌入式储存的材料。相关论文于2019年12月9日在线发表于国际学术期刊《自然—生物技术》。

研究人员设计了一种叫做“DNA-of-things”(DoT)存储体系结构来生产具有不变内存的材料。在DoT框架中,DNA分子记录数据,然后将这些分子封装在纳米二氧化硅珠中,将其融合成各种材料,这些材料可用于打印或铸造任何形状的物体。首先,研究人员将DoT应用于三维打印斯坦福兔子(Stanford Bunny)的过程,其中包含一个45 kB的数字DNA蓝图以进行合成。研究人员合成了五代兔子,每一代都来自上一代的储存,而且没有出现额外的DNA合成或信息降解。为了测试DoT的可扩展性,研究人员在有机玻璃眼镜镜片中的DNA中存储了一个1.4 MB的视频,并通过切开一小块有机玻璃并对嵌入的DNA进行测序来对其进行检索。DoT可以用于在医疗植入物中存储电子健康记录,隐藏日常对象(密写)中的数据以及制造包含其自身蓝图的对象。它也可以促进自动复制机的开发。

据了解,DNA存储可提供大量的信息密度和出色的半衰期。

附:英文原文

Title: A DNA-of-things storage architecture to create materials with embedded memory

Author: Julian Koch, Silvan Gantenbein, Kunal Masania, Wendelin J. Stark, Yaniv Erlich, Robert N. Grass

Issue&Volume: 2019-12-09

Abstract: DNA storage offers substantial information density1,2,3,4,5,6,7 and exceptional half-life3. We devised a ‘DNA-of-things’ (DoT) storage architecture to produce materials with immutable memory. In a DoT framework, DNA molecules record the data, and these molecules are then encapsulated in nanometer silica beads8, which are fused into various materials that are used to print or cast objects in any shape. First, we applied DoT to three-dimensionally print a Stanford Bunny9 that contained a 45kB digital DNA blueprint for its synthesis. We synthesized five generations of the bunny, each from the memory of the previous generation without additional DNA synthesis or degradation of information. To test the scalability of DoT, we stored a 1.4MB video in DNA in plexiglass spectacle lenses and retrieved it by excising a tiny piece of the plexiglass and sequencing the embedded DNA. DoT could be applied to store electronic health records in medical implants, to hide data in everyday objects (steganography) and to manufacture objects containing their own blueprint. It may also facilitate the development of self-replicating machines.

DOI: 10.1038/s41587-019-0356-z

Source: https://www.nature.com/articles/s41587-019-0356-z

Nature Biotechnology:《自然—生物技术》,创刊于1996年。隶属于施普林格·自然出版集团,最新IF:31.864
官方网址:https://www.nature.com/nbt/
投稿链接:https://mts-nbt.nature.com/cgi-bin/main.plex


本期文章:《自然—生物技术》:Online/在线发表

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