美国加州理工学院高伟团队研发出一种激光雕刻的可穿戴传感器，其可用于灵敏检测汗液中的尿酸和的酪氨酸。相关论文于11月25日在线发表于《自然—生物技术》。
研究人员报道了一个完全激光雕刻的传感器，可同时进行汗液采样、化学传感和生命体征监测。研究人员证明了对温度、呼吸频率以及低浓度尿酸和酪氨酸、痛风和代谢紊乱等疾病相关分析物的持续检测。在运动后和富含蛋白质的饮食之后，研究人员在经过身体训练和未经训练的受试者中测试该设备的性能。
研究人员还通过富含嘌呤的膳食改变评估其在痛风监测患者和健康对照中的功能。痛风患者的汗液中尿酸水平高于健康个体，血清中也观察到类似趋势。
据悉，穿戴式汗液传感器可用于持续测量有用的生物标志物。但是，当前的传感器不能准确地检测低的分析物浓度、缺乏多模式感测或难以大规模制造。
附：英文原文
Title: A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat
Author: Yiran Yang, Yu Song, Xiangjie Bo, Jihong Min, On Shun Pak, Lailai Zhu, Minqiang Wang, Jiaobing Tu, Adam Kogan, Haixia Zhang, Tzung K. Hsiai, Zhaoping Li, Wei Gao
Issue&Volume: 2019-11-25
Abstract: Wearable sweat sensors have the potential to provide continuous measurements of useful biomarkers. However, current sensors cannot accurately detect low analyte concentrations, lack multimodal sensing or are difficult to fabricate at large scale. We report an entirely laser-engraved sensor for simultaneous sweat sampling, chemical sensing and vital-sign monitoring. We demonstrate continuous detection of temperature, respiration rate and low concentrations of uric acid and tyrosine, analytes associated with diseases such as gout and metabolic disorders. We test the performance of the device in both physically trained and untrained subjects under exercise and after a protein-rich diet. We also evaluate its utility for gout monitoring in patients and healthy controls through a purine-rich meal challenge. Levels of uric acid in sweat were higher in patients with gout than in healthy individuals, and a similar trend was observed in serum.
DOI: 10.1038/s41587-019-0321-x
Source: https://www.nature.com/articles/s41587-019-0321-x
Nature Biotechnology：《自然—生物技术》，创刊于1996年。隶属于施普林格·自然出版集团，最新IF：68.164
官方网址：https://www.nature.com/nbt/
投稿链接：https://mts-nbt.nature.com/cgi-bin/main.plex
本期文章：《自然—生物技术》：Online/在线发表
