小柯机器人

葡萄牙里斯本大学João T. Barata介绍了 IL-7和IL-7R调控健康和疾病发生中的双重功能。该综述11月19日在线发表在《自然—免疫学》上。

细胞因子IL-7及其受体IL-7R对T细胞极其重要，同时对小鼠B细胞的发育、初始T细胞的分化和存活以及记忆T细胞的产生和维持也很重要。它们也是先天淋巴细胞（ILC）发育和维持所必需的，因此对于淋巴结构的产生和防御屏障也必不可少。本文研究人员讨论了IL-7和IL-7R在淋巴系统中的核心作用，并指出了它们失控的影响，特别是它们促进癌症发展“阴暗面”的功能。

研究人员还探讨了与IL-7–IL-7R信号通路正向或负向调控相关的治疗意义和时机。

附：英文原文

Title: Flip the coin: IL-7 and IL-7R in health and disease

Author: Joo T. Barata, Scott K. Durum, Benedict Seddon

Issue&Volume: 2019-11-19

Abstract: The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive T cells, and generation and maintenance of memory T cells. They are also required for innate lymphoid cell (ILC) development and maintenance, and consequently for generation of lymphoid structures and barrier defense. Here we discuss the central role of IL-7 and IL-7R in the lymphoid system and highlight the impact of their deregulation, placing a particular emphasis on their ‘dark side’ as promoters of cancer development. We also explore therapeutic implications and opportunities associated with either positive or negative modulation of the IL-7–IL-7R signaling axis.

DOI: 10.1038/s41590-019-0479-x

Source: https://www.nature.com/articles/s41590-019-0479-x

Nature Immunology：《自然—免疫学》，创刊于2000年。隶属于施普林格·自然出版集团，最新IF：31.25
官方网址：https://www.nature.com/ni/
投稿链接：https://mts-ni.nature.com/cgi-bin/main.plex