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研究总结心脏代谢紊乱中的性别差异
2019-11-11 21:30

挪威卑尔根大学Eva Gerdts等研究人员对心脏代谢紊乱中性别差异进行了总结性回顾。这一综述论文2019年11月7日在线发表在国际学术期刊《自然—医学》上。

据研究人员介绍,在世界范围内,男女心脏代谢疾病的患病率均在上升,并且与肥胖和肥胖相关的其他心脏代谢危险因素(例如高血压、糖调节异常和血脂异常)的聚集有关。但是,常见的心脏代谢紊乱类型(如心力衰竭、心房颤动和局部缺血性心脏病)主要是性别特异的,人们对这些疾病和潜在机制的识别才刚刚出现。新证据表明,性激素、性别特异性分子机制以及性别会影响葡萄糖和脂质的代谢以及心脏能量的代谢和功能。

研究人员回顾了心脏代谢风险因素、相关的临床前和临床心脏疾病以及潜在治疗途径中的性别差异。

附:英文原文

Title: Sex differences in cardiometabolic disorders

Author: Eva Gerdts, Vera Regitz-Zagrosek

Issue&Volume: 2019-11-07

Abstract: The prevalence of cardiometabolic disorders in both women and men has increased worldwide and is linked to a rise in obesity and obesity-associated associated clustering of other cardiometabolic risk factors such as hypertension, impaired glucose regulation and dyslipidemia. However, the predominance of common types of cardiometabolic disorders such as heart failure, atrial fibrillation and ischemic heart disease is sex specific, and our identification of these and the underlying mechanisms is only just emerging. New evidence suggests that sex hormones, sex-specific molecular mechanisms and gender influence glucose and lipid metabolisms, as well as cardiac energy metabolism, and function. Here we review sex differences in cardiometabolic risk factors, associated preclinical and clinical cardiac disorders and potential therapeutic avenues. Sex differences in the prevalence, risk factors and symptoms of cardiometabolic disorders are being elucidated and should be taken into account in diagnosis and treatment.

DOI: 10.1038/s41591-019-0643-8

Source:https://www.nature.com/articles/s41591-019-0643-8

Nature Medicine:《自然—医学》,创刊于1995年。隶属于施普林格·自然出版集团,最新IF:87.241
官方网址:https://www.nature.com/nm/
投稿链接:https://mts-nmed.nature.com/cgi-bin/main.plex


本期文章:《自然—医学》:Online/在线发表

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