美国缅因州医学中心Elizabeth Rendina-Ruedy等研究人员对骨髓中脂质的功能进行了总结性展望。10月24日，《细胞—代谢》杂志在线发表了相关文章。
据研究人员介绍，由于维持骨骼动态平衡需要大量能量，因此骨骼系统通过神经元和激素介体与全身代谢密切相关。葡萄糖、氨基酸和脂肪酸是其重建过程中骨驻留细胞的主要燃料来源。骨髓中的脂质可以是有效的脂肪酸来源。
因此，尽管先前的研究已经提出骨髓中的脂肪细胞起着“填充物”的作用，并且对骨骼的体内稳态有害，但研究人员认为，事实上，骨髓脂质对于骨骼的正常功能至关重要。
因此，研究人员回顾了有关骨骼微环境内脂质的存储、使用和输出的主要证据，包括来自体外和体内模型系统的脂质。研究人员还强调了仍然要充分认识到脂质转换与骨骼稳态之间关系的众多挑战。
附：英文原文
Title: Lipids in the Bone Marrow: An Evolving Perspective
Author: Elizabeth Rendina-Ruedy, Clifford J. Rosen
Issue&Volume: 2019/10/24
Abstract: Because of heavy energy demands to maintain bone homeostasis, the skeletal system is closely tied to whole-body metabolism via neuronal and hormonal mediators. Glucose, amino acids, and fatty acids are the chief fuel sources for bone resident cells during its remodeling. Lipids, which can be mobilized from intracellular depots in the bone marrow, can be a potent source of fatty acids. Thus, while it has been suggested that adipocytes in the bone marrow act as “filler” and are detrimental to skeletal homeostasis, we propose that marrow lipids are, in fact, essential for proper bone functioning. As such, we examine the prevailing evidence regarding the storage, use, and export of lipids within the skeletal niche, including from both in vitro and in vivo model systems. We also highlight the numerous challenges that remain to fully appreciate the relationship of lipid turnover to skeletal homeostasis.
DOI: 10.1016/j.cmet.2019.09.015
Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30518-2
Cell Metabolism：《细胞—代谢》，创刊于2005年。隶属于细胞出版社，最新IF：31.373
官方网址：https://www.cell.com/cell-metabolism/home
投稿链接：https://www.editorialmanager.com/cell-metabolism/default.aspx
本期文章：《细胞—代谢》：Online/在线发表
