小柯机器人

调节性T细胞亚群限制肺纤维化发生
2019-10-08 15:20

日本千叶大学Toshinori Nakayama研究组发现,CD103高表达的调节性T细胞能够限制由CD103 低表达的组织常驻致病性CD4 T细胞所引起的肺纤维化。2019年10月7日,国际知名学术期刊《自然—免疫学》在线发表了这一成果。

研究人员发现,CD69高表达CD103低表达的CD4阳性组织驻留记忆T细胞(TRM细胞)产生效应细胞因子,并促进由长期暴露于烟曲霉引起的炎症和纤维化反应。同时,诱导了免疫抑制性CD69高表达CD103高表达Foxp3和CD4双阳性调节性T细胞,并限制了致病性CD103低表达的TRM细胞引起纤维化的能力。因此,肺组织驻留的CD4阳性T细胞在慢性肺部炎症的病理中起关键作用,而CD103的表达定义了炎症肺部中的致病效应子和免疫抑制组织驻留的细胞亚群。

据了解, TRM细胞是非淋巴组织中适应性免疫的关键介导者。然而,存在于慢性炎症性病变内的CD4阳性TRM细胞的功能异质性和致病作用仍然未知。

附:英文原文

Title: CD103 hi T reg cells constrain lung fibrosis induced by CD103 lo tissue-resident pathogenic CD4 T cells

Author: Tomomi Ichikawa, Kiyoshi Hirahara, Kota Kokubo, Masahiro Kiuchi, Ami Aoki, Yuki Morimoto, Jin Kumagai, Atsushi Onodera, Naoko Mato, Damon J. Tumes, Yoshiyuki Goto, Koichi Hagiwara, Yutaka Inagaki, Tim Sparwasser, Kazuyuki Tobe, Toshinori Nakayama

Issue&Volume: 2019-10-07

Abstract: 

Tissue-resident memory T cells (TRM cells) are crucial mediators of adaptive immunity in nonlymphoid tissues. However, the functional heterogeneity and pathogenic roles of CD4+ TRM cells that reside within chronic inflammatory lesions remain unknown. We found that CD69hiCD103lo CD4+ TRM cells produced effector cytokines and promoted the inflammation and fibrotic responses induced by chronic exposure to Aspergillus fumigatus. Simultaneously, immunosuppressive CD69hiCD103hiFoxp3+ CD4+ regulatory T cells were induced and constrained the ability of pathogenic CD103lo TRM cells to cause fibrosis. Thus, lung tissue-resident CD4+ T cells play crucial roles in the pathology of chronic lung inflammation, and CD103 expression defines pathogenic effector and immunosuppressive tissue-resident cell subpopulations in the inflamed lung.

DOI: 10.1038/s41590-019-0494-y

Source: https://www.nature.com/articles/s41590-019-0494-y

Nature Immunology:《自然—免疫学》,创刊于2000年。隶属于施普林格·自然出版集团,最新IF:31.25
官方网址:https://www.nature.com/ni/
投稿链接:https://mts-ni.nature.com/cgi-bin/main.plex


本期文章:《自然—免疫学》:Online/在线发表

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