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Tanycytes能够调节脂质稳态
2019-08-30 14:12

瑞士洛桑大学Luc Pellerin 和Sarah Geller课题组合作发现Tanycytes(下丘脑室管膜 - 胶质细胞)通过感知游离脂肪酸,由FGF21的分泌向下丘脑的关键神经元群发送信号来调节脂质稳态。相关论文2019年8月29日在线发表于《细胞—代谢》。

研究人员观察到tanycytes产生并分泌Fgf21,并且分布于靠近Fgf21敏感神经元的位置。禁食,可能通过循环脂肪酸的增加,调节这种核心Fgf21的产生Tanycytes将棕榈酸盐储存在脂滴中并氧化它,导致活性氧(ROS)/ p38-MAPK信号通路的激活。这对于棕榈酸暴露后氧化导致的tanycytic Fgf21表达是必需的。Tanycytic Fgf21缺失导致脂肪分解代谢加快,可能是由于禁食期间重要神经元的抑制受损。针对tanycytic Fgf21缺失的小鼠表现出能量消耗的增加和脂肪质量增加的减少,使人联想到褐变表型。他们的研究结果表明,tanycytes通过下丘脑内的Fgf21信号传导感知游离脂肪酸以维持体脂稳态。

据了解,下丘脑在能量底物检测调节能量稳态过程中起着重要作用。Tanycytes,即下丘脑室管膜 - 胶质细胞,在整合多种外周输入途径中处于有利位置。

附:英文原文

Title: Tanycytes Regulate Lipid Homeostasis by Sensing Free Fatty Acids and Signaling to Key Hypothalamic Neuronal Populations via FGF21 Secretion

Author: Sarah Geller, Yoan Arribat, Citlalli Netzahualcoyotzi, Sylviane Lagarrigue, Lionel Carneiro, Lianjun Zhang, Francesca Amati, Isabel C. Lopez-Mejia, Luc Pellerin

Issue&Volume: 29 August 2019

Abstract: The hypothalamus plays a key role in the detection of energy substrates to regulate energy homeostasis. Tanycytes, the hypothalamic ependymo-glia, are located at a privileged position to integrate multiple peripheral inputs. We observed that tanycytes produce and secrete Fgf21 and are located close to Fgf21-sensitive neurons. Fasting, likely via the increase in circulating fatty acids, regulates this central Fgf21 production. Tanycytes store palmitate in lipid droplets and oxidize it, leading to the activation of a reactive oxygen species (ROS)/p38-MAPK signaling pathway, which is essential for tanycytic Fgf21 expression upon palmitate exposure. Tanycytic Fgf21 deletion triggers an increase in lipolysis, likely due to impaired inhibition of key neurons during fasting. Mice deleted for tanycytic Fgf21 exhibit increased energy expenditure and a reduction in fat mass gain, reminiscent of a browning phenotype. Our results suggest that tanycytes sense free fatty acids to maintain body lipid homeostasis through Fgf21 signaling within the hypothalamus.

DOI: https://doi.org/10.1016/j.cmet.2019.08.004

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30433-4#

Cell Metabolism:《细胞—代谢》,创刊于2005年。隶属于细胞出版社,最新IF:31.373
官方网址:https://www.cell.com/cell-metabolism/home
投稿链接:https://www.editorialmanager.com/cell-metabolism/default.aspx


本期文章:《细胞—代谢》:Online/在线发表

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