8 August, 2013 Volume 51, Issue 3 On the cover: Cell-specific transcriptional responses to extra- and intracellular signals require the combined activities of promoters and enhancers. Although recent studies suggest a hierarchical model in which lineage-determining factors prime cell-speci ...
1 August, 2013 Volume 154, Issue 3 On the cover: Feeding Drosophila a diet high in sugar leads to metabolic defects, including hyperglycemia, hyperinsulinemia, and insulin resistance. In this issue, Hirabayashi et al. (pp. 664–675) now show that high dietary sugar converts Ras/Src-tra ...
Epigenetic phenomenon of dosage compensation in Drosophila is mediated by the male-specific lethal (MSL) complex, which contains two large noncoding roX RNAs in Drosophila . How these RNAs interact with the MSL proteins remains poorly understood. In this study, Ilik et al. (156–173) ...
某次会议上我问过某大牛类似的问题， 我本以为会是***先把这个文章发出来。科研竞争惨烈，旁观者enjoy成果吧 ~ Tumor suppressor gene Rb is required for self-renewal of spermatogonial stem cells in mice. Hu YC , de Rooij DG , Page DC . Source Whitehead Institute, ...
Arginine Methylation Initiates BMP-Induced Smad Signaling 11 July, 2013 Volume 51, Issue 1 On the cover: Signaling by cell-surface receptors is commonly mediated by kinases, resulting in phosphorylation of receptors and signaling effectors. The TGF-β-related BMP ligands act as growth ...
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