An Inherently Bifunctional Subset of Foxp3 + T Helper Cells Is Controlled by the Transcription Factor Eos Highlights A subset of Treg cells shows labile expression of the corepressor Eos These Treg cells can reprogram into helper cells without losing Foxp3 Eos-labile Treg cells ...
Nature immunology:Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function Phagocytosis is a fundamental cellular process that is pivotal for immunity as it coordinates microbial killing, innate immune activation and antigen presentati ...
Nature immunology:Natural and inducible T H 17 cells are regulated differently by Akt and mTOR pathways Natural T helper 17 (nT H 17) cells are a population of interleukin 17 (IL-17)-producing cells that acquire effector function in the thymus during development. Here we demonstrate that the seri ...
Cell: Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance Highlights: Neutrophils undergo a process of aging during their lifetime in circulation Neutrophil clearance reduces the size and function of the hematopoietic niche Macrophages and LXR receptors mediate ...