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静远嘲风封面设计作品-Cell Reports

已有 2153 次阅读 2015-3-11 13:04 |个人分类:发表作品|系统分类:论文交流

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期刊:
Cell Reports
Volume 10, Issue 9, 10 March 2015


原文标题:

KDEL Receptors Assist Dengue Virus Exit from the Endoplasmic Reticulum

原文作者:
Ming Yuan Li, Marc Grandadam, Kevin Kwok, Thibault Lagache, Yu Lam Siu, Jing Shu Zhang, Kouxiong Sayteng, Mateusz Kudelko, Cheng Feng Qin, Jean-Christophe Olivo-Marin, Roberto Bruzzone, Pei Gang Wang

原文摘要:
Membrane receptors at the surface of target cells are key host factors for virion entry; however, it is unknown whether trafficking and secretion of progeny virus requires host intracellular receptors. In this study, we demonstrate that dengue virus (DENV) interacts with KDEL receptors (KDELR), which cycle between the ER and Golgi apparatus, for vesicular transport from ER to Golgi. Depletion of KDELR by siRNA reduced egress of both DENV progeny and recombinant subviral particles (RSPs). Coimmunoprecipitation of KDELR with dengue structural protein prM required three positively charged residues at the N terminus, whose mutation disrupted protein interaction and inhibited RSP transport from the ER to the Golgi. Finally, siRNA depletion of class II Arfs, which results in KDELR accumulation in the Golgi, phenocopied results obtained with mutagenized prME and KDELR knockdown. Our results have uncovered a function for KDELR as an internal receptor involved in DENV trafficking.

原文链接:
http://www.cell.com/cell-reports/abstract/S2211-1247(15)00167-9




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