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Cover Story
The eukaryotic genome isfunctionally and spatially organized within the cell nucleus. How these spatialorganizations regulate genome function remains largely unclear. This review (pages 255-268) provides an overview on cytological observations of subnucleargene positioning, and summarizes recent findings onthe molecular mechanisms of gene positioning and genome function.
Visualizing and tracking specific DNA sequences in the cell nucleus canprovide critical information on the spatiotemporal regulation of physiologicalprocesses including transcription, replication and repair. DNA fluorescence in situ hybridization(FISH) allowsdetermining the subnuclear localizations of specificDNA sequences infixed cells, while thelacO/lacI system and the m6A tracer technology enablethree-dimensional tracking of DNA elements inliving cells.The obtained information from these imaging assayscan be correlated with functional activities of these DNA elementsand with genome-wide analyses. Together these techniques willyield important advances in our understandings ofnuclear organizations,epigenetics and genome function.
The cover image in this issue illustrates currentcell imaging tools to detect subnucleargene positioning. DNA FISH, lacO/lacIsystem, and m6A tracertechnology.(Seepages 255-268 by Nidhi Vishnoi and Jie Yao for more information)
Contents
Volume 9 issue 4
Reviews
Gene positioning and genome function
IRF4 and IRF8:governing the virtues of B lymphocytes
Research articles
Age-related peculiarities of change in content of free radical oxidation products in muscle during stress
Vadim V. DAVYDOV1,*(),Amjad HAMDALLAH2,Evgenya R. GRABOVETSKAYA3
http://www.frontiers-biology.org
Current trends of antibiotic resistance in clinical isolates of Staphylococcus aureus
Kapil Dev SHARMA1,2,Rajendra Prasad SAINI1,Loganathan KARTHIK2,*()
http://www.frontiers-biology.org
Isolation and partial purification of fungal ligninolytic enzymes from the forest soil fungi isolated from Bhadra Wildlife Sanctuary
SHIVAKUMAR P. BANAKAR1,*(),B. THIPPESWAMY2
http://www.frontiers-biology.org
Bioactive compounds from Caulerpa racemosa as a potent larvicidal and antibacterial agent
Sowmya Rachannanavar NAGARAJ,Jabez William OSBORNE()
http://www.frontiers-biology.org
Isolation and characterization of tyrosinase produced by marine actinobacteria and its application in the removal of phenol from aqueous environment
Suki ROY1,Ishita DAS1,Minki MUNJAL1,Loganathan KARTHIK1,2,Gaurav KUMAR1,2,Sathish KUMAR1,Kokati Venkata Bhaskara RAO1,*()
http://www.frontiers-biology.org
Lucrative pectinase production by novel strain Pseudozyma sp. SPJ with statistical optimization techniques using agro-industrial residues
Sampriya SHARMA(),Jitender SHARMA,Rishi Pal MANDHAN
http://www.frontiers-biology.org
Apathy in Parkinson disease
Marina NODEL1,*(),Nikolay YAKHNO1,Anastasia MEDVEDEVA1,Michail KULIKOV2
http://www.frontiers-biology.org
Cognitive disorder in brain concussion
Vladimir ZAKHAROV1,*(),Ekaterina DROZDOVA2,Nikolay YAKHNO1
http://www.frontiers-biology.org
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